Education
Ph.D. in Cell Biology, University of Massachusetts Medical School, Worcester, MA, 2004
Current position
Assistant Professor, Dept. of Biochemistry, University of Mississippi Medical Center, Jackson, MS
Publications
Note: publications with “Blomberg, M" and "Blomberg-Wirschell, M” use the author's maiden name and former hyphenated last name respectively.
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Wirschell, M., Olbrich, H., Werner, C., Tritschler, D., Bower, R., Sale, W. S., Loges, N. T., Pennekamp, P., Lindberg, S., Stenram, U., Carlen, B., Horak, E., Kohler, G., Nurnberg, P., Nurnberg, G., Porter, M. E. and Omran, H. (2013). The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. Nat Genet 45(3): 262-268.
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Yamamoto, R., Song, K., Yanagisawa, H. A., Fox, L., Yagi, T., Wirschell, M., Hirono, M., Kamiya, R., Nicastro, D. and Sale, W. S. (2013). The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility. J Cell Biol 201(2): 263-278.
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Wirschell, M., Yamamoto, R., Alford, L., Gokhale, A., Gaillard, A. and Sale, W. S. (2011). Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme. Arch Biochem Biophys 510(2): 93-100.
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Alford, L., Wirschell, M., Yamamoto, R. and Sale, W. S. (2011). Control of axonemal inner dynein arms. Dyneins: Structure, Biology and Disease: 313.
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Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K. and Sale, W. S. (2011). An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility. Cytoskeleton (Hoboken) 68(7): 363-372.
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Wirschell, M., and Dutcher, SK. (2011). Algal Flagella. Encyclopedia of Life Sciences. www.els.net.
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Hom, E. F., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. and King, S. M. (2011). A unified taxonomy for ciliary dyneins. Cytoskeleton (Hoboken) 68(10): 555-565.
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Gokhale, A., Wirschell, M., Sale, W. S. and Mitchell, D. M. (2010). Regulation of ciliary and flagellar dyneins. In The Dynein Handbook, edited by Linda Amos. Book Chapter in press.
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Wirschell, M., Nicastro, D., Porter, M. E. and Sale, W. S. (2009). Structural basis for regulation of flagellar motility: organization of the dynein regulatory complex, inter-dynein linkers and a network of axonemal kinases and phosphatases. The Chlamydomonas Sourcebook. G.B. Witman, editor.
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Ikeda, K., Yamamoto, R., Wirschell, M., Yagi, T., Bower, R., Porter, M. E., Sale, W. S. and Kamiya, R. (2009). A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii. Cell Motil Cytoskeleton 66(8): 448-456.
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Wirschell, M., Yang, C., Yang, P., Fox, L., Yanagisawa, H. A., Kamiya, R., Witman, G. B., Porter, M. E. and Sale, W. S. (2009). IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. Mol Biol Cell 20(13): 3044-3054.
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Bower, R., VanderWaal, K., O'Toole, E., Fox, L., Perrone, C., Mueller, J., Wirschell, M., Kamiya, R., Sale, W. S. and Porter, M. E. (2009). IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility. Mol Biol Cell 20(13): 3055-3063.
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Elam, C. A., Sale, W. S. and Wirschell, M. (2009). The regulation of dynein-driven microtubule sliding in Chlamydomonas flagella by axonemal kinases and phosphatases. Methods Cell Biol 92: 133-151.
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Yang, P., Yang, C., Wirschell, M. and Davis, S. (2009). Novel LC8 mutations have disparate effects on the assembly and stability of flagellar complexes. J Biol Chem 284(45): 31412-31421.
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Gokhale, A., Wirschell, M. and Sale, W. S. (2009). Regulation of dynein-driven microtubule sliding by the axonemal protein kinase CK1 in Chlamydomonas flagella. J Cell Biol 186(6): 817-824.
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Wirschell, M., Zhao, F., Yang, C., Yang, P., Diener, D., Gaillard, A., Rosenbaum, J. L. and Sale, W. S. (2008). Building a radial spoke: flagellar radial spoke protein 3 (RSP3) is a dimer. Cell Motil Cytoskeleton 65(3): 238-248.
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Wirschell, M., Hendrickson, T. and Sale, W. S. (2007). Keeping an eye on I1: I1 dynein as a model for flagellar dynein assembly and regulation. Cell Motil Cytoskeleton 64(8): 569-579.
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Wirschell, M., Pazour, G., Yoda, A., Hirono, M., Kamiya, R. and Witman, G. B. (2004). Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Mol Biol Cell 15(6): 2729-2741.
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Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogensen, M., Groisman, I., Blomberg, M. and Doxsey, S. (2003). A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. J Cell Biol 161(3): 535-545.
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Blomberg, M., Rao, S., Reilly, J., Tiarks, C., Peters, S., Kittler, E. and Quesenberry, P. (1998). Repetitive bone marrow transplantation in nonmyeloablated recipients. Exp Hematol 26(4): 320-324.
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Blomberg-Wirschell, M. and Doxsey, S. J. (1998). Rapid isolation of centrosomes. Methods Enzymol 298: 228-238.
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Quesenberry, P. J., Ramshaw, H., Crittenden, R. B., Stewart, F. M., Rao, S., Peters, S., Becker, P., Lowry, P., Blomberg, M., Reilly, J. and et al. (1994). Engraftment of normal murine marrow into nonmyeloablated host mice. Blood Cells 20(2-3): 348-350
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Koevary, S. B. and Blomberg, M. (1992). Prevention of diabetes in BB/Wor rats by intrathymic islet injection. J Clin Invest 89(2): 512-516.