Odile Mercereau-Puijalon Parasite Molecular Immunology Unit, Institut Pasteur, France
2 protocols

Micheline Guillotte Institut Pasteur
2 protocols

Inès Vigan-Womas
  • Institut Pasteur
Research focus
  • Microbiology
  • 2 Author merit


Ph.D. in Molecular and Cellular biology, University Joseph FOURIER, Grenoble, France, 2001

Current position

Researcher at Institut Pasteur of Paris, CNRS URA 2581, Molecular Parasite Immunology Unit, Department of Parasitology and Mycology


  1. Vigan-Womas, I., Guillotte, M., Juillerat, A., Hessel, A., Raynal, B., England, P., Cohen, J. H., Bertrand, O., Peyrard, T., Bentley, G. A., Lewit-Bentley, A. and Mercereau-Puijalon, O. (2012). Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting. PLoS Pathog 8(7): e1002781.
  2. Janes, J. H., Wang, C. P., Levin-Edens, E., Vigan-Womas, I., Guillotte, M., Melcher, M., Mercereau-Puijalon, O. and Smith, J. D. (2011). Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family. PLoS Pathog 7(5): e1002032.
  3. Migot-Nabias, F., Lokossou, A. G., Vigan-Womas, I., Guitard, E., Guillotte, M., Noukpo, J. M., Mercereau-Puijalon, O., Dugoujon, J. M. and Garcia, A. (2011). Combined effects of Gm or Km immunoglobulin allotypes and age on antibody responses to Plasmodium falciparum VarO rosetting variant in Benin. Microbes Infect 13(8-9): 771-775.
  4. Juillerat, A., Lewit-Bentley, A., Guillotte, M., Gangnard, S., Hessel, A., Baron, B., Vigan-Womas, I., England, P., Mercereau-Puijalon, O. and Bentley, G. A. (2011). Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition. Proc Natl Acad Sci U S A 108(13): 5243-5248.
  5. Vigan-Womas, I., Guillotte, M., Juillerat, A., Vallieres, C., Lewit-Bentley, A., Tall, A., Baril, L., Bentley, G. A. and Mercereau-Puijalon, O. (2011). Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes. PLoS ONE 6(1): e16544.
  6. Vigan-Womas, I., Lokossou, A., Guillotte, M., Juillerat, A., Bentley, G., Garcia, A., Mercereau-Puijalon, O. and Migot-Nabias, F. (2010). The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children. Malar J 9: 267.
  7. Melcher, M., Muhle, R. A., Henrich, P. P., Kraemer, S. M., Avril, M., Vigan-Womas, I., Mercereau-Puijalon, O., Smith, J. D. and Fidock, D. A. (2010). Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells. Cell Microbiol 12(10): 1446-1462.
  8. Juillerat, A., Igonet, S., Vigan-Womas, I., Guillotte, M., Gangnard, S., Faure, G., Baron, B., Raynal, B., Mercereau-Puijalon, O. and Bentley, G. A. (2010). Biochemical and biophysical characterisation of DBL1alpha1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum. Mol Biochem Parasitol 170(2): 84-92.
  9. Vigan-Womas, I., Guillotte, M., Le Scanf, C., Igonet, S., Petres, S., Juillerat, A., Badaut, C., Nato, F., Schneider, A., Lavergne, A., Contamin, H., Tall, A., Baril, L., Bentley, G. A. and Mercereau-Puijalon, O. (2008). An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype. Infect Immun 76(12): 5565-5580.
  10. Safeukui, I., Correas, J. M., Brousse, V., Hirt, D., Deplaine, G., Mule, S., Lesurtel, M., Goasguen, N., Sauvanet, A., Couvelard, A., Kerneis, S., Khun, H., Vigan-Womas, I., Ottone, C., Molina, T. J., Treluyer, J. M., Mercereau-Puijalon, O., Milon, G., David, P. H. and Buffet, P. A. (2008). Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen. Blood 112(6): 2520-2528.
  11. Mercereau-Puijalon, O., Guillotte, M. and Vigan-Womas, I. (2008). Rosetting in Plasmodium falciparum: a cytoadherence phenotype with multiple actors. Transfus Clin Biol 15(1-2): 62-71.
  12. Le Scanf, C., Vigan-Womas, I., Contamin, H., Guillotte, M., Bischoff, E. and Mercereau-Puijalon, O. (2008). Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey. Microbes Infect 10(4): 447-451.
  13. Boeuf, P., Vigan-Womas, I., Jublot, D., Loizon, S., Barale, J. C., Akanmori, B. D., Mercereau-Puijalon, O. and Behr, C. (2005). CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use. BMC Immunol 6: 5.
  14. Leroy, V., Vigan, I., Mosnier, J. F., Dufeu-Duchesne, T., Pernollet, M., Zarski, J. P., Marche, P. N. and Jouvin-Marche, E. (2003). Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C. Hepatology 38(4): 829-841.
  15. Vigan, I., Jouvin-Marche, E., Leroy, V., Pernollet, M., Tongiani-Dashan, S., Borel, E., Delachanal, E., Colomb, M., Zarski, J. P. and Marche, P. N. (2003). T lymphocytes infiltrating the liver during chronic hepatitis C infection express a broad range of T-cell receptor beta chain diversity. J Hepatol 38(5): 651-659.
  16. Pernollet, M., Jouvin-Marche, E., Leroy, V., Vigan, I., Zarski, J. P. and Marche, P. N. (2002). Simultaneous evaluation of lymphocyte subpopulations in the liver and in peripheral blood mononuclear cells of HCV-infected patients: relationship with histological lesions. Clin Exp Immunol 130(3): 518-525.
  17. Brenier-Pinchart, M. P., Vigan, I., Jouvin-Marche, E., Marche, P. N., Pelet, E., Gross, U., Ambroise-Thomas, P. and Pelloux, H. (2002). Monocyte chemotactic protein-1 secretion and expression after Toxoplasma gondii infection in vitro depend on the stage of the parasite. FEMS Microbiol Lett 214(1): 45-49.
  18. Derouich-Guergour, D., Aldebert, D., Vigan, I., Jouvin-Marche, E., Marche, P. N., Aubert, D., Ambroise-Thomas, P. and Pelloux, H. (2002). Toxoplasma gondii infection can regulate the expression of tumour necrosis factor-alpha receptors on human cells in vitro. Parasite Immunol 24(5): 271-279.
  19. Jouvin-Marche E., Vigan I., Leroy V. and Marche P. N. (2000). Quantitative RT-PCR for the detection of T cell receptor transcripts in T lymphocytes populations using LightCycler technology. Rapid Cycle Real Time PCR – Methods and Applications. In: Meuer M., Wittwer C., Nakagawara K. I. (eds). Vergla Berlin Heidelberg New York. Springer, 263 – 271.
2 Protocols published
Authors:  Inès Vigan-Womas, Micheline Guillotte and Odile Mercereau-Puijalon, date: 04/20/2013, view: 13365, Q&A: 0
Rosetting, i.e. the capacity of red blood cells (iRBCs) infected with mature parasite stages to bind two or more uninfected red blood cells (RBCs) is a virulence factor of Plasmodium falciparum. This protocol describes an in vitro ...
Authors:  Micheline Guillotte, Odile Mercereau-Puijalon and Inès Vigan-Womas, date: 04/20/2013, view: 9048, Q&A: 0
Rosetting, i.e. the capacity of Plasmodium falciparum-infected red blood cells (iRBCs) to bind two or more uninfected red blood cells (RBCs) is associated with severe malaria in African children. Disruption of rosettes using small ...
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