Education

M.D., College of Medicine, National Taiwan University, 1979

Ph.D., Graduate Institute of Clinical Medicine, National Taiwan University,1990

Current Positions

Professor, Department of Internal Medicine, College of Medicine, National Taiwan University (1993-present)
Academician, Academia Sinica (2006-present)
President, National Taiwan University (2013-present)

Publications (selected)

1. Chen, W. J., Ho, C. C., Chang, Y. L., Chen, H. Y., Lin, C. A., Ling, T. Y., Yu, S. L., Yuan, S. S., Chen, Y. J., Lin, C. Y., Pan, S. H., Chou, H. Y., Chen, Y. J., Chang, G. C., Chu, W. C., Lee, Y. M., Lee, J. Y., Lee, P. J., Li, K. C., Chen, H. W. and Yang, P. C. (2014). Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat Commun 5: 3472.
2. Kao, S. H., Wang, W. L., Chen, C. Y., Chang, Y. L., Wu, Y. Y., Wang, Y. T., Wang, S. P., Nesvizhskii, A. I., Chen, Y. J., Hong, T. M. and Yang, P. C. (2014). GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene 33(24): 3172-3182.
3. Chen, C. Y., Jan, C. I., Lo, J. F., Yang, S. C., Chang, Y. L., Pan, S. H., Wang, W. L., Hong, T. M. and Yang, P. C. (2013). Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation. Cancer Res 73(13): 4009-4019.
4. Lin, C. W., Chang, Y. L., Chang, Y. C., Lin, J. C., Chen, C. C., Pan, S. H., Wu, C. T., Chen, H. Y., Yang, S. C., Hong, T. M. and Yang, P. C. (2013). MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun 4: 1877.
5. Chang, Y. C., Yang, C. Y., Sun, R. L., Cheng, Y. F., Kao, W. C. and Yang, P. C. (2013). Rapid single cell detection of Staphylococcus aureus by aptamer-conjugated gold nanoparticles. Sci Rep 3: 1863.
6. Hsu, Y. C., Chen, H. Y., Yuan, S., Yu, S. L., Lin, C. H., Wu, G., Yang, P. C. and Li, K. C. (2013). Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity. BMC Med 11: 106.
7. Chen, J. S., Chan, W. K., Tsai, K. T., Hsu, H. H., Lin, C. Y., Yuan, A., Chen, W. J., Lai, H. S. and Yang, P. C. (2013). Simple aspiration and drainage and intrapleural minocycline pleurodesis versus simple aspiration and drainage for the initial treatment of primary spontaneous pneumothorax: an open-label, parallel-group, prospective, randomised, controlled trial. Lancet 381(9874): 1277-1282.
8. Lan, Q., Hsiung, C. A., Matsuo, K., Hong, Y. C., Seow, A., Wang, Z., Hosgood, H. D., 3rd, Chen, K., Wang, J. C., Chatterjee, N., Hu, W., Wong, M. P., Zheng, W., Caporaso, N., Park, J. Y., Chen, C. J., Kim, Y. H., Kim, Y. T., Landi, M. T., Shen, H., Lawrence, C., Burdett, L., Yeager, M., Yuenger, J., Jacobs, K. B., Chang, I. S., Mitsudomi, T., Kim, H. N., Chang, G. C., Bassig, B. A., Tucker, M., Wei, F., Yin, Z., Wu, C., An, S. J., Qian, B., Lee, V. H., Lu, D., Liu, J., Jeon, H. S., Hsiao, C. F., Sung, J. S., Kim, J. H., Gao, Y. T., Tsai, Y. H., Jung, Y. J., Guo, H., Hu, Z., Hutchinson, A., Wang, W. C., Klein, R., Chung, C. C., Oh, I. J., Chen, K. Y., Berndt, S. I., He, X., Wu, W., Chang, J., Zhang, X. C., Huang, M. S., Zheng, H., Wang, J., Zhao, X., Li, Y., Choi, J. E., Su, W. C., Park, K. H., Sung, S. W., Shu, X. O., Chen, Y. M., Liu, L., Kang, C. H., Hu, L., Chen, C. H., Pao, W., Kim, Y. C., Yang, T. Y., Xu, J., Guan, P., Tan, W., Su, J., Wang, C. L., Li, H., Sihoe, A. D., Zhao, Z., Chen, Y., Choi, Y. Y., Hung, J. Y., Kim, J. S., Yoon, H. I., Cai, Q., Lin, C. C., Park, I. K., Xu, P., Dong, J., Kim, C., He, Q., Perng, R. P., Kohno, T., Kweon, S. S., Chen, C. Y., Vermeulen, R., Wu, J., Lim, W. Y., Chen, K. C., Chow, W. H., Ji, B. T., Chan, J. K., Chu, M., Li, Y. J., Yokota, J., Li, J., Chen, H., Xiang, Y. B., Yu, C. J., Kunitoh, H., Wu, G., Jin, L., Lo, Y. L., Shiraishi, K., Chen, Y. H., Lin, H. C., Wu, T., Wu, Y. L., Yang, P. C., Zhou, B., Shin, M. H., Fraumeni, J. F., Jr., Lin, D., Chanock, S. J. and Rothman, N. (2012). Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet 44(12): 1330-1335.
9. Lin, J. C., Wu, Y. Y., Wu, J. Y., Lin, T. C., Wu, C. T., Chang, Y. L., Jou, Y. S., Hong, T. M. and Yang, P. C. (2012). TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. EMBO Mol Med 4(6): 472-485.
10. Lin, P. Y. and Yang, P. C. (2011). Circulating miRNA signature for early diagnosis of lung cancer. EMBO Mol Med 3(8): 436-437.
11. Yuan, S., Yu, S. L., Chen, H. Y., Hsu, Y. C., Su, K. Y., Chen, H. W., Chen, C. Y., Yu, C. J., Shih, J. Y., Chang, Y. L., Cheng, C. L., Hsu, C. P., Hsia, J. Y., Lin, C. Y., Wu, G., Liu, C. H., Wang, C. D., Yang, K. C., Chen, Y. W., Lai, Y. L., Hsu, C. C., Lin, T. C., Yang, T. Y., Chen, K. C., Hsu, K. H., Chen, J. J., Chang, G. C., Li, K. C. and Yang, P. C. (2011). Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. J Clin Oncol 29(25): 3435-3442.
12. Pan, S. H., Chao, Y. C., Hung, P. F., Chen, H. Y., Yang, S. C., Chang, Y. L., Wu, C. T., Chang, C. C., Wang, W. L., Chan, W. K., Wu, Y. Y., Che, T. F., Wang, L. K., Lin, C. Y., Lee, Y. C., Kuo, M. L., Lee, C. H., Chen, J. J., Hong, T. M. and Yang, P. C. (2011). The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest 121(8): 3189-3205.
13. Ho, B. C., Yu, S. L., Chen, J. J., Chang, S. Y., Yan, B. S., Hong, Q. S., Singh, S., Kao, C. L., Chen, H. Y., Su, K. Y., Li, K. C., Cheng, C. L., Cheng, H. W., Lee, J. Y., Lee, C. N. and Yang, P. C. (2011). Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host Microbe 9(1): 58-69.
14. Wu, Y. Y., Peck, K., Chang, Y. L., Pan, S. H., Cheng, Y. F., Lin, J. C., Yang, R. B., Hong, T. M. and Yang, P. C. (2011). SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer. Oncogene 30(34): 3682-3693.
15. Chang, T. H., Tsai, M. F., Su, K. Y., Wu, S. G., Huang, C. P., Yu, S. L., Yu, Y. L., Lan, C. C., Yang, C. H., Lin, S. B., Wu, C. P., Shih, J. Y. and Yang, P. C. (2011). Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor. Am J Respir Crit Care Med 183(8): 1071-1079.
16. Hsiung, C. A., Lan, Q., Hong, Y. C., Chen, C. J., Hosgood, H. D., Chang, I. S., Chatterjee, N., Brennan, P., Wu, C., Zheng, W., Chang, G. C., Wu, T., Park, J. Y., Hsiao, C. F., Kim, Y. H., Shen, H., Seow, A., Yeager, M., Tsai, Y. H., Kim, Y. T., Chow, W. H., Guo, H., Wang, W. C., Sung, S. W., Hu, Z., Chen, K. Y., Kim, J. H., Chen, Y., Huang, L., Lee, K. M., Lo, Y. L., Gao, Y. T., Kim, J. H., Liu, L., Huang, M. S., Jung, T. H., Jin, G., Caporaso, N., Yu, D., Kim, C. H., Su, W. C., Shu, X. O., Xu, P., Kim, I. S., Chen, Y. M., Ma, H., Shen, M., Cha, S. I., Tan, W., Chang, C. H., Sung, J. S., Zhang, M., Yang, T. Y., Park, K. H., Yuenger, J., Wang, C. L., Ryu, J. S., Xiang, Y., Deng, Q., Hutchinson, A., Kim, J. S., Cai, Q., Landi, M. T., Yu, C. J., Park, J. Y., Tucker, M., Hung, J. Y., Lin, C. C., Perng, R. P., Boffetta, P., Chen, C. Y., Chen, K. C., Yang, S. Y., Hu, C. Y., Chang, C. K., Fraumeni, J. F., Jr., Chanock, S., Yang, P. C., Rothman, N. and Lin, D. (2010). The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet 6(8).
17. Wang, S. P., Wang, W. L., Chang, Y. L., Wu, C. T., Chao, Y. C., Kao, S. H., Yuan, A., Lin, C. W., Yang, S. C., Chan, W. K., Li, K. C., Hong, T. M. and Yang, P. C. (2009). p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 11(6): 694-704.
18. Shih, T. T., Hou, H. A., Liu, C. Y., Chen, B. B., Tang, J. L., Chen, H. Y., Wei, S. Y., Yao, M., Huang, S. Y., Chou, W. C., Hsu, S. C., Tsay, W., Yu, C. W., Hsu, C. Y., Tien, H. F. and Yang, P. C. (2009). Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival. Blood 113(14): 3161-3167.
19. Chao, Y. C., Pan, S. H., Yang, S. C., Yu, S. L., Che, T. F., Lin, C. W., Tsai, M. S., Chang, G. C., Wu, C. H., Wu, Y. Y., Lee, Y. C., Hong, T. M. and Yang, P. C. (2009). Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med 179(2): 123-133.
20. Yang, C. H., Yu, C. J., Shih, J. Y., Chang, Y. C., Hu, F. C., Tsai, M. C., Chen, K. Y., Lin, Z. Z., Huang, C. J., Shun, C. T., Huang, C. L., Bean, J., Cheng, A. L., Pao, W. and Yang, P. C. (2008). Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy. J Clin Oncol 26(16): 2745-2753.
21. Wu, J. Y., Yu, C. J., Yang, C. H., Wu, S. G., Chiu, Y. H., Gow, C. H., Chang, Y. C., Hsu, Y. C., Wei, P. F., Shih, J. Y. and Yang, P. C. (2008). First- or second-line therapy with gefitinib produces equal survival in non-small cell lung cancer. Am J Respir Crit Care Med 178(8): 847-853.
22. Ho, C. C., Liao, W. Y., Wang, C. Y., Lu, Y. H., Huang, H. Y., Chen, H. Y., Chan, W. K., Chen, H. W. and Yang, P. C. (2008). TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am J Respir Crit Care Med 177(7): 763-770.
23. Yu, S. L., Chen, H. Y., Chang, G. C., Chen, C. Y., Chen, H. W., Singh, S., Cheng, C. L., Yu, C. J., Lee, Y. C., Chen, H. S., Su, T. J., Chiang, C. C., Li, H. N., Hong, Q. S., Su, H. Y., Chen, C. C., Chen, W. J., Liu, C. C., Chan, W. K., Chen, W. J., Li, K. C., Chen, J. J. and Yang, P. C. (2008). MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 13(1): 48-57.
24. Chen, H. W., Lee, J. Y., Huang, J. Y., Wang, C. C., Chen, W. J., Su, S. F., Huang, C. W., Ho, C. C., Chen, J. J., Tsai, M. F., Yu, S. L. and Yang, P. C. (2008). Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 68(18): 7428-7438.
25. Wang, C. C., Tsai, M. F., Dai, T. H., Hong, T. M., Chan, W. K., Chen, J. J. and Yang, P. C. (2007). Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1. Cancer Res 67(10): 4816-4826.
26. Chen, H. Y., Yu, S. L., Chen, C. H., Chang, G. C., Chen, C. Y., Yuan, A., Cheng, C. L., Wang, C. H., Terng, H. J., Kao, S. F., Chan, W. K., Li, H. N., Liu, C. C., Singh, S., Chen, W. J., Chen, J. J. and Yang, P. C. (2007). A five-gene signature and clinical outcome in non-small-cell lung cancer. N Engl J Med 356(1): 11-20.
27. Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. and Yang, P. C. (2007). Targeting neuropilin 1 as an antitumor strategy in lung cancer. Clin Cancer Res 13(16): 4759-4768.
28. Tsai, M. F., Wang, C. C., Chang, G. C., Chen, C. Y., Chen, H. Y., Cheng, C. L., Yang, Y. P., Wu, C. Y., Shih, F. Y., Liu, C. C., Lin, H. P., Jou, Y. S., Lin, S. C., Lin, C. W., Chen, W. J., Chan, W. K., Chen, J. J. and Yang, P. C. (2006). A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J Natl Cancer Inst 98(12): 825-838.
29. Su, J. L., Yang, P. C., Shih, J. Y., Yang, C. Y., Wei, L. H., Hsieh, C. Y., Chou, C. H., Jeng, Y. M., Wang, M. Y., Chang, K. J., Hung, M. C. and Kuo, M. L. (2006). The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9(3): 209-223.
30. Shih, J. Y., Tsai, M. F., Chang, T. H., Chang, Y. L., Yuan, A., Yu, C. J., Lin, S. B., Liou, G. Y., Lee, M. L., Chen, J. J., Hong, T. M., Yang, S. C., Su, J. L., Lee, Y. C. and Yang, P. C. (2005). Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res 11(22): 8070-8078.
31. Yang, C. H., Huang, C. J., Yang, C. S., Chu, Y. C., Cheng, A. L., Whang-Peng, J. and Yang, P. C. (2005). Gefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family protein. Cancer Res 65(15): 6943-6949.
32. Shih, J. Y., Gow, C. H. and Yang, P. C. (2005). EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer. N Engl J Med 353(2): 207-208.
33. Chen, J. J., Lin, Y. C., Yao, P. L., Yuan, A., Chen, H. Y., Shun, C. T., Tsai, M. F., Chen, C. H. and Yang, P. C. (2005). Tumor-associated macrophages: the double-edged sword in cancer progression. J Clin Oncol 23(5): 953-964.
34. Yuan, A., Yu, C. J., Luh, K. T., Kuo, S. H., Lee, Y. C. and Yang, P. C. (2002). Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer. J Clin Oncol 20(4): 900-910.
35. Shih, J. Y., Yang, S. C., Hong, T. M., Yuan, A., Chen, J. J., Yu, C. J., Chang, Y. L., Lee, Y. C., Peck, K., Wu, C. W. and Yang, P. C. (2001). Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells.J Natl Cancer Inst 93(18): 1392-1400.
36. Chen, J. J., Peck, K., Hong, T. M., Yang, S. C., Sher, Y. P., Shih, J. Y., Wu, R., Cheng, J. L., Roffler, S. R., Wu, C. W. and Yang, P. C. (2001). Global analysis of gene expression in invasion by a lung cancer model. Cancer Res 61(13): 5223-5230. 2.
37. Yuan, A., Yu, C. J., Kuo, S. H., Chen, W. J., Lin, F. Y., Luh, K. T., Yang, P. C. and Lee, Y. C. (2001). Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer. J Clin Oncol 19(2): 432-441.
38. Yang, P. C. (2000). Ultrasound-guided transthoracic biopsy of the chest. Radiol Clin North Am 38(2): 323-343.
39. Peck, K., Sher, Y. P., Shih, J. Y., Roffler, S. R., Wu, C. W. and Yang, P. C. (1998). Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. Cancer Res 58(13): 2761-2765.