Sabrina Rizzolio Laboratory of Cancer Cell Biology, Candiolo Cancer Institute and Department of Oncology of the University of Torino, Italy
1 protocol

Luca Tamagnone
  • Department of Oncology, University of Torino, Candiolo Cancer Institute-IRCCS, Italy
Research focus
  • Cell biology
  • 1 Author merit


Ph.D. in Human Oncology, University of Torino, Italy, 1997

M.D., University of Torino - Medical School, Italy, 1991

Current position

Lab head and Associate Professor in the Department of Oncology of the University of Torino, c/o Institute for Cancer Research in Candiolo (IRCC)

Publications (short selected list)

  1. Tamagnone, L. (2012). Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer. Cancer Cell 22(2): 145-152.
  2. Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J., Neufeld, G. and Tamagnone, L. (2012). Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Res 72(22): 5801-5811.
  3. Casazza, A., Kigel, B., Maione, F., Capparuccia, L., Kessler, O., Giraudo, E., Mazzone, M., Neufeld, G. and Tamagnone, L. (2012). Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. EMBO Mol Med 4(3): 234-250.
  4. Casazza, A., Fu, X., Johansson, I., Capparuccia, L., Andersson, F., Giustacchini, A., Squadrito, M. L., Venneri, M. A., Mazzone, M., Larsson, E., Carmeliet, P., De Palma, M., Naldini, L., Tamagnone, L.* and Rolny, C.* (2011). Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. Arterioscler Thromb Vasc Biol 31(4): 741-749. (*corresponding senior author)
  5. Casazza, A., Finisguerra, V., Capparuccia, L., Camperi, A., Swiercz, J. M., Rizzolio, S., Rolny, C., Christensen, C., Bertotti, A., Sarotto, I., Risio, M., Trusolino, L., Weitz, J., Schneider, M., Mazzone, M., Comoglio, P. M. and Tamagnone, L. (2010). Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J Clin Invest 120(8): 2684-2698.
  6. Capparuccia, L. and Tamagnone, L. (2009). Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin. J Cell Sci 122(Pt 11): 1723-1736.
  7. Rolny, C., Capparuccia, L., Casazza, A., Mazzone, M., Vallario, A., Cignetti, A., Medico, E., Carmeliet, P., Comoglio, P. M. and Tamagnone, L. (2008). The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. J Exp Med 205(5): 1155-1171.
  8. Franco, M. and Tamagnone, L. (2008). Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive. EMBO Rep 9(9): 865-871.
  9. Barberis, D., Artigiani, S., Casazza, A., Corso, S., Giordano, S., Love, C. A., Jones, E. Y., Comoglio, P. M. and Tamagnone, L. (2004). Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility. FASEB J 18(3): 592-594.
  10. Tamagnone, L. and Comoglio, P. M. (2004). To move or not to move? Semaphorin signalling in cell migration. EMBO Rep 5(4): 356-361.
  11. Tamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G. I., Song, H., Chedotal, A., Winberg, M. L., Goodman, C. S., Poo, M., Tessier-Lavigne, M. and Comoglio, P. M. (1999). Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99(1): 71-80.
1 Protocol published
A549 细胞中的表皮生长因子(GCF)受体内吞作用分析
Authors:  Sabrina Rizzolio and Luca Tamagnone, date: 08/05/2013, view: 16472, Q&A: 0
The following endocytosis assay has been optimized to assess EGF-stimulated EGFR endocytosis; but could be modified to assess other ligand-stimulated endocytosis of plasma membrane receptors (for which fluorochrome-conjugated ligands are available ...
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