Hamiyet Unal
  • Molecular Cardiology, Cleveland Clinic, USA
Research focus
  • Cell biology
  • 1 Author merit


Ph.D. in Regulatory Biology, Cellular and Molecular Medicine Specialization, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA, 2010

Current position

Research Associate, Cleveland Clinic, Lerner Research Institute, Molecular Cardiology, Cleveland, OH


  1. Unal, H., Jagannathan, R., Bhatnagar, A., Tirupula, K., Desnoyer, R. and Karnik, S. S. (2013). Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor. J Biol Chem 288(1): 540-551.    
  2. Bhatnagar, A., Unal, H., Jagannathan, R., Kaveti, S., Duan, Z. H., Yong, S., Vasanji, A., Kinter, M., Desnoyer, R. and Karnik, S. S. (2013). Interaction of G-protein betagamma complex with chromatin modulates GPCR-dependent gene regulation. PLoS One 8(1): e52689.
  3. Karnik, S. S. and Unal, H. (2012). Angiotensin II receptor-induced cardiac remodeling in mice without angiotensin II. Hypertension 59(3): 542-544.    
  4. Unal, H. and Karnik, S. S. (2012). Domain coupling in GPCRs: the engine for induced conformational changes. Trends Pharmacol Sci 33(2): 79-88.
  5. Unal, H., Jagannathan, R. and Karnik, S. S. (2012). Mechanism of GPCR-directed autoantibodies in diseases. Adv Exp Med Biol 749: 187-199.    
  6. Unal, H., Jagannathan, R., Bhat, M. B. and Karnik, S. S. (2010). Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor. J Biol Chem 285(21): 16341-16350.   
1 Protocol published
Author:  Hamiyet Unal, date: 06/20/2013, view: 21802, Q&A: 0
Calcium mobilization assay is a cell-based second messenger assay to measure the calcium flux associated with Gq-protein coupled receptor activation or inhibition. The method utilizes a calcium sensitive fluorescent dye that is taken up into the ...
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