Zhengui Xia Department of Environmental Health and Toxicology, University of Washington, USA
1 protocol

Xuanmao Chen University of Washington
1 protocol

Daniel R. Storm
  • Department of Pharmacology, University of Washington, USA
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D. in Biochemistry, University of California, Berkley, 1971

Current position

Professor University of Washington, Pharmacology (07/1982-present)

Publications (Since 2010)

  1. Wang, W., Lu, S., Li, T., Pan, Y. W., Zou, J., Abel, G. M., Xu, L., Storm, D. R. and Xia, Z. (2015). Inducible activation of ERK5 MAP kinase enhances adult neurogenesis in the olfactory bulb and improves olfactory function. J Neurosci 35(20): 7833-7849.
  2. Luo, J., Chen, X., Pan, Y. W., Lu, S., Xia, Z. and Storm, D. R. (2015). The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb. PLoS One 10(3): e0122057.
  3. Connelly, T., Yu, Y., Grosmaitre, X., Wang, J., Santarelli, L. C., Savigner, A., Qiao, X., Wang, Z., Storm, D. R. and Ma, M. (2015). G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons. Proc Natl Acad Sci U S A 112(2): 590-595.
  4. Chen, X., Cao, H., Saraf, A., Zweifel, L. S. and Storm, D. R. (2015). Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. J Neurosci 35(1): 339-351.
  5. Wardlaw, S. M., Phan, T. X., Saraf, A., Chen, X. and Storm, D. R. (2014). Genetic disruption of the core circadian clock impairs hippocampus-dependent memory. Learn Mem 21(8): 417-423.
  6. Liu, J., Chan, G. Hecht, A., Storm, D. R. and Davis, G (2013). Nasal saline irrigation has no effect on normal olfaction: A prospective randomized trial. Int Forum Allergy Rhinol 4:39-42.
  7.  Saraf, A., Luo, J., Morris, D. R. and Storm, D. R. (2014). Phosphorylation of eukaryotic translation initiation factor 4E and eukaryotic translation initiation factor 4E-binding protein (4EBP) and their upstream signaling components undergo diurnal oscillation in the mouse hippocampus: implications for memory persistence. J Biol Chem 289(29): 20129-20138.
  8. Liu, J. J., Chan, G. C., Hecht, A. S., Storm, D. R. and Davis, G. E. (2014). Comparison of two nasal cell collection methods in determining cyclic adenosine monophosphate levels and its association with olfaction: A feasibility study. Allergy Rhinol (Providence) 5(1): 17-21.
  9. Wang, W., Pan, Y. W., Zou, J., Li, T., Abel, G. M., Palmiter, R. D., Storm, D. R. and Xia, Z. (2014). Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci 34(6): 2130-2147.
  10. Chen, Y. Z., Friedman, J. R., Chen, D. H., Chan, G. C., Bloss, C. S., Hisama, F. M., Topol, S. E., Carson, A. R., Pham, P. H., Bonkowski, E. S., Scott, E. R., Lee, J. K., Zhang, G., Oliveira, G., Xu, J., Scott-Van Zeeland, A. A., Chen, Q., Levy, S., Topol, E. J., Storm, D., Swanson, P. D., Bird, T. D., Schork, N. J., Raskind, W. H. and Torkamani, A. (2014). Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia. Ann Neurol 75(4): 542-549.
  11. Corder, G., Doolen, S., Donahue, R. R., Winter, M. K., Jutras, B. L., He, Y., Hu, X., Wieskopf, J. S., Mogil, J. S., Storm, D. R., Wang, Z. J., McCarson, K. E. and Taylor, B. K. (2013). Constitutive mu-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science 341(6152): 1394-1399.
  12. Nakashima, A., Takeuchi, H., Imai, T., Saito, H., Kiyonari, H., Abe, T., Chen, M., Weinstein, L. S., Yu, C. R., Storm, D. R., Nishizumi, H. and Sakano, H. (2013). Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons. Cell 154(6): 1314-1325.
  13. Hwang, C. K., Chaurasia, S. S., Jackson, C. R., Chan, G. C., Storm, D. R. and Iuvone, P. M. (2013). Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci 33(38): 14989-14997.
  14. Zou, J., Storm, D. R. and Xia, Z. (2013). Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviors. PLoS One 8(10): e76901.
  15. Chen, X., Xia, Z. and Storm, D. R. (2013). Electroolfactogram (EOG) recording in the mouse main olfactory epithelium. Bio-protocol 3(11): e789.
  16. Luo, J., Phan, T. X., Yang, Y., Garelick, M. G. and Storm, D. R. (2013). Increases in cAMP, MAPK activity, and CREB phosphorylation during REM sleep: implications for REM sleep and memory consolidation. J Neurosci 33(15): 6460-6468.
  17. Li, T., Pan, Y. W., Wang, W., Abel, G., Zou, J., Xu, L., Storm, D. R. and Xia, Z. (2013). Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb. PLoS One 8(4): e61948.
  18. Pan, Y. W., Storm, D. R.* and Xia, Z.* (2013). Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: new insights from ERK5 MAP kinase. Neurobiol Learn Mem 105: 81-92. (*Corresponding authors)
  19. Pan, Y. W., Kuo, C. T., Storm, D. R. and Xia, Z. (2012). Inducible and targeted deletion of the ERK5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior. PLoS One 7(11): e49622.
  20. Chen, X., Xia, Z. and Storm, D. R. (2012). Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. J Neurosci 32(45): 15769-15778.
  21. Pan, Y. W., Storm, D. R. and Xia, Z. (2012). The maintenance of established remote contextual fear memory requires ERK5 MAP kinase and ongoing adult neurogenesis in the hippocampus. PLoS One 7(11): e50455.
  22. Tsai, L. C., Chan, G. C., Nangle, S. N., Shimizu-Albergine, M., Jones, G. L., Storm, D. R., Beavo, J. A. and Zweifel, L. S. (2012). Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav 11(7): 837-847.
  23. Charles, J. F., Coury, F., Sulyanto, R., Sitara, D., Wu, J., Brady, N., Tsang, K., Sigrist, K., Tollefsen, D. M., He, L., Storm, D. and Aliprantis, A. O. (2012). The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone 51(5): 902-912.
  24. Xia, Z. and Storm, D. R. (2012). Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory. Learn Mem 19(9): 369-374.    
  25. Pan, Y. W., Zou, J., Wang, W., Sakagami, H., Garelick, M. G., Abel, G., Kuo, C. T., Storm, D. R. and Xia, Z. (2012). Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis. J Biol Chem 287(28): 23306-23317.
  26. Pan, Y. W., Chan, G. C., Kuo, C. T., Storm, D. R. and Xia, Z. (2012). Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory. J Neurosci 32(19): 6444-6455.
  27. Zou, J., Pan, Y. W., Wang, Z., Chang, S. Y., Wang, W., Wang, X., Tournier, C., Storm, D. R. and Xia, Z. (2012). Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. J Neurosci 32(12): 4118-4132.
  28. Sindreu, C. and Storm, D. R. (2011). Modulation of neuronal signal transduction and memory formation by synaptic zinc. Front Behav Neurosci 5: 68.
  29. Lim, J. H., Davis, G. E., Rue, T. C. and Storm, D. R. (2012). Human sinonasal explant system for testing cytotoxicity of intranasal agents. Int Forum Allergy Rhinol 2(1): 63-68.
  30. Wang, H., Liu, H., Storm, D. R. and Zhang, Z. W. (2011). Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus. J Physiol 589(Pt 23): 5649-5662
  31. Phan, T. X., Chan, G. C., Sindreu, C. B., Eckel-Mahan, K. L. and Storm, D. R. (2011). The diurnal oscillation of MAP (mitogen-activated protein) kinase and adenylyl cyclase activities in the hippocampus depends on the suprachiasmatic nucleus. J Neurosci 31(29): 10640-10647.
  32. Zhang, M., Storm, D. R. and Wang, H. (2011). Bidirectional synaptic plasticity and spatial memory flexibility require Ca2+-stimulated adenylyl cyclases. J Neurosci 31(28): 10174-10183.
  33. Wang, Z., Phan, T. and Storm, D. R. (2011). The type 3 adenylyl cyclase is required for novel object learning and extinction of contextual memory: role of cAMP signaling in primary cilia. J Neurosci 31(15): 5557-5561.
  34. Leen, J. L., Izzo, A., Upadhyay, C., Rowland, K. J., Dube, P. E., Gu, S., Heximer, S. P., Rhodes, C. J., Storm, D. R., Lund, P. K. and Brubaker, P. L. (2011). Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology 152(2): 436-446
  35. Wang, Z. and Storm, D. R. (2011). Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclase. Neuropsychopharmacology 36(4): 772-781.
  36. Sindreu, C., Palmiter, R. D. and Storm, D. R. (2011). Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory. Proc Natl Acad Sci U S A 108(8): 3366-3370.
  37. Xiao, Z., He, L., Takemoto, M., Jalanko, H., Chan, G. C., Storm, D. R., Betsholtz, C., Tryggvason, K. and Patrakka, J. (2011). Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria. Nephron Exp Nephrol 118(3): e39-48.
  38. Shimizu, K., Mackenzie, S. M. and Storm, D. R. (2010). SCOP/PHLPP and its functional role in the brain. Mol Biosyst 6(1): 38-43.
  39. Shan, Q. and Storm, D. R. (2010). Optimization of a cAMP response element signal pathway reporter system. J Neurosci Methods 191(1): 21-25.
  40. Lambert, T, Storm, DR,  and Sullivan, J, (2010) MicroRNA132 Modulates Short-Term Synaptic Plasticity but Not Basal Release Probability in Hippocampal Neurons. PloS ONE. e 315182. PMCID: PMC301207
  41. Nudelman, A. S., DiRocco, D. P., Lambert, T. J., Garelick, M. G., Le, J., Nathanson, N. M. and Storm, D. R. (2010). Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus 20(4): 492-498.

1 Protocol published
Electroolfactogram (EOG) Recording in the Mouse Main Olfactory Epithelium
Authors:  Xuanmao Chen, Zhengui Xia and Daniel R. Storm, date: 06/05/2013, view: 7457, Q&A: 0
Olfactory sensory neurons in the main olfactory epithelium (MOE) are responsible for detecting odorants and EOG recording is a reliable approach to analyze the peripheral olfactory function. However, recently we revealed that rodent MOE can also ...
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