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Andrea Introini Karolinska Institutet
8 protocols

Balaji Olety Amaranath University of Massachusetts medical School
2 protocols

Dennis Nürnberg Imperial College London
36 protocols

Emilie Viennois Georgia State University
3 protocols

Reviewer
Kathrin Sutter
  • University of Duisburg-Essen
Research focus
  • Immunology
  • 2 Author merit
2 Protocols published
Measurement of IFN-α Subtype Concentrations (Virus-free, Cell-based Bioassay)
Author:  Kathrin Gibbert, date: 06/20/2013, view: 3940, Q&A: 0
The induction of type I IFN is the immediate host response against viral infections. Type I IFNs belong to a multigene family including up to 14 different IFN-α subtypes and one IFN-β. They are highly conserved and bind the same receptor (IFNAR1/2) ...
IFN-α Inhibition Assay in vitro
Author:  Kathrin Gibbert, date: 06/20/2013, view: 4488, Q&A: 0
During viral infections Interferon-α (IFN-α) is expressed by infected host cells. IFN-α binds to its receptor (IFNAR1/2), which leads to the activation of downstream signaling via JAK-STAT. This signaling cascade results in the expression of several ...
13 Protocols reviewed
Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies
Authors:  Chie Aoki-Utsubo, Ming Chen and Hak Hotta, date: 05/20/2018, view: 16, Q&A: 0
In a narrow definition, virucidal activity represents the activity by which to interact with and physically disrupt viral particles. In a broad definition, it includes the activity by which to functionally inhibit (neutralize) viral infectivity ...
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Alphavirus Purification Using Low-speed Spin Centrifugation
Chemical and sedimentation procedures are used to purify virus particles. While these approaches are successful for wild-type viruses, they are often not feasible for purifying mutant viruses with assembly defects. We combined two published methods ...
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