Elrike Frenzel Department of Molecular Genetics, Rijksuniversiteit Groningen/ Groningen Biomolecular Sciences and Biotechnology Institute, The Netherlands
1 protocol

Monika Ehling-Schulz
  • Department of Pathobiology, University of Veterinary Medicine Vienna/Institute of Microbiology, Austria
Research focus
  • Microbiology
  • 1 Author merit


PhD (Dr. rer. nat.) in Microbiology, Technische Universitat München, 2000

Current position

Full Professor for Functional Microbiology at the University of Veterinary Medicine, Vienna, Austria

Publications (since 2005)

  1. Stark, T., Marxen, S., Rutschle, A., Lucking, G., Scherer, S., Ehling-Schulz, M. and Hofmann, T. (2013). Mass spectrometric profiling of Bacillus cereus strains and quantitation of the emetic toxin cereulide by means of stable isotope dilution analysis and HEp-2 bioassay. Anal Bioanal Chem 405(1): 191-201.
  2. Dzieciol M., M. Fricker, M. Wagner, I. Hein, and M. Ehling-Schulz. (2012). A diagnostic real-time PCR assay for quantification and differentiation of emetic and non-emetic Bacillus cereus in milk, Food Control, in press.
  3. Ehling-Schulz M., and U. Messelhausser. (2012). One pathogen but two different types of food borne outbreaks; Bacillus cereus in catering facilities in Germany. p .63-70. In: Hoorfar J. (Ed.), Case studies in food safety and quality management: Lessons from real-life situations. Woodhead Publishing, Cambridge, UK.
  4. Frenzel, E., Doll, V., Pauthner, M., Lucking, G., Scherer, S. and Ehling-Schulz, M. (2012). CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits. Mol Microbiol 85(1): 67-88.
  5. Josefsen, M. H., Bonnichsen, L., Larsson, J. T., Nielsen, E. M., Fricker, M., Ehling-Schulz, M., Hoorfar, J. and Christensen, L. S. (2012). Evaluation of flaA short variable region sequencing, multilocus sequence typing, and Fourier transform infrared spectroscopy for discrimination between Campylobacter jejuni strains. Food Analytical Methods 5(5): 980-987.
  6. Messelhausser U. und M. Ehling-Schulz (2012). Bacillus cereus. p. 1-13. In: Baumgart J. B. Becker, und R. Stephan (Eds.), Mikrobiologische Untersuchung von Lebensmitteln. Behr’s Verlag , Hamburg, Germany.
  7. Dommel, M. K., Lucking, G., Scherer, S. and Ehling-Schulz, M. (2011). Transcriptional kinetic analyses of cereulide synthetase genes with respect to growth, sporulation and emetic toxin production in Bacillus cereus. Food Microbiol 28(2): 284-290.
  8. Ehling-Schulz M., R. Knutsson, and S. Scherer. (2011). Bacillus cereus. p. 147-164. In: Kathariou S., P. Fratamico, and Y. Liu (Eds.), Genomes of Food- and Water-Borne Pathogens. ASM Press. Washington D.C., USA.
  9. Ehling-Schulz M., U. Messelhausser, and P.E. Granum. (2011). Bacillus cereus in milk and dairy production. p. 275-289. In: Hoorfar J. (Ed.), Rapid Detection, Characterization and Enumeration of Food- Borne Pathogens. ASM Press. Washington D.C., USA.
  10. Frenzel, E., Letzel, T., Scherer, S. and Ehling-Schulz, M. (2011). Inhibition of cereulide toxin synthesis by emetic Bacillus cereus via long-chain polyphosphates. Appl Environ Microbiol 77(4): 1475-1482.
  11. Fricker, M., Skanseng, B., Rudi, K., Stessl, B. and Ehling-Schulz, M. (2011). Shift from farm to dairy tank milk microbiota revealed by a polyphasic approach is independent from geographical origin. Int J Food Microbiol 145 Suppl 1: S24-30.
  12. Fricker, M., Agren, J., Segerman, B., Knutsson, R. and Ehling-Schulz, M. (2011). Evaluation of Bacillus strains as model systems for the work on Bacillus anthracis spores. Int J Food Microbiol 145 Suppl 1: S129-136.
  13. Knutsson, R., van Rotterdam, B., Fach, P., De Medici, D., Fricker, M., Lofstrom, C., Agren, J., Segerman, B., Andersson, G., Wielinga, P., Fenicia, L., Skiby, J., Schultz, A. C. and Ehling-Schulz, M. (2011). Accidental and deliberate microbiological contamination in the feed and food chains--how biotraceability may improve the response to bioterrorism. Int J Food Microbiol 145 Suppl 1: S123-128.
  14. Segerman, B., De Medici, D., Ehling Schulz, M., Fach, P., Fenicia, L., Fricker, M., Wielinga, P., Van Rotterdam, B. and Knutsson, R. (2011). Bioinformatic tools for using whole genome sequencing as a rapid high resolution diagnostic typing tool when tracing bioterror organisms in the food and feed chain. Int J Food Microbiol 145 Suppl 1: S167-176.
  15. Stessl B., I. Hein, M. Wagner, and M. Ehling-Schulz. (2011). Staphylococcus aureus in the dairy chain. p. 291-305. In: Hoorfar J. (Ed.), Rapid Detection, Characterization and Enumeration of Food- Borne Pathogens. ASM Press. Washington D.C., USA.
  16. Wagener K., Idris R., Prunner I., Klein D., Ehling-Schulz M., and M. Drillich. (2011). Den Tatern auf der Spur – Nachweis von Escherichia coli und Arcanobacterium pyogenes im Uterus des Rindes. VetMedReport, Blackwell Publishing, 9/11, 3-5.
  17. Wielinga, P. R., Hamidjaja, R. A., Agren, J., Knutsson, R., Segerman, B., Fricker, M., Ehling-Schulz, M., de Groot, A., Burton, J., Brooks, T., Janse, I. and van Rotterdam, B. (2011). A multiplex real-time PCR for identifying and differentiating B. anthracis virulent types. Int J Food Microbiol 145 Suppl 1: S137-144.
  18. Witthuhn, M., Luecking, G., Atamer, Z., EHLING‐SCHULZ, M. and Hinrichs, J. (2011). Thermal resistance of aerobic spore formers isolated from food products. International journal of dairy technology 64(4): 486-493.
  19. Bauer, T., Stark, T., Hofmann, T. and Ehling-Schulz, M. (2010). Development of a stable isotope dilution analysis for the quantification of the Bacillus cereus toxin cereulide in foods. J Agric Food Chem 58(3): 1420-1428.
  20. Biesta-Peters, E. G., Reij, M. W., Blaauw, R. H., In 't Veld, P. H., Rajkovic, A., Ehling-Schulz, M. and Abee, T. (2010). Quantification of the emetic toxin cereulide in food products by liquid chromatography-mass spectrometry using synthetic cereulide as a standard. Appl Environ Microbiol 76(22): 7466-7472.
  21. Dommel, M. K., Frenzel, E., Strasser, B., Blochinger, C., Scherer, S. and Ehling-Schulz, M. (2010). Identification of the main promoter directing cereulide biosynthesis in emetic Bacillus cereus and its application for real-time monitoring of ces gene expression in foods. Appl Environ Microbiol 76(4): 1232-1240.
  22. Messelhausser, U., Kampf, P., Fricker, M., Ehling-Schulz, M., Zucker, R., Wagner, B., Busch, U. and Holler, C. (2010). Prevalence of emetic Bacillus cereus in different ice creams in Bavaria. J Food Prot 73(2): 395-399.
  23. Ehling-Schulz M. and M. Fricker. (2009). Mastitisdiagnostik - neue Technologien für ein altes Problem. Klauentierpraxis, 17, 116-120.
  24. Lucking, G., Dommel, M. K., Scherer, S., Fouet, A. and Ehling-Schulz, M. (2009). Cereulide synthesis in emetic Bacillus cereus is controlled by the transition state regulator AbrB, but not by the virulence regulator PlcR. Microbiology 155(Pt 3): 922-931.
  25. Fricker, M., Reissbrodt, R. and Ehling-Schulz, M. (2008). Evaluation of standard and new chromogenic selective plating media for isolation and identification of Bacillus cereus. Int J Food Microbiol 121(1): 27-34.
  26. Guinebretiere, M. H., Thompson, F. L., Sorokin, A., Normand, P., Dawyndt, P., Ehling-Schulz, M., Svensson, B., Sanchis, V., Nguyen-The, C., Heyndrickx, M. and De Vos, P. (2008). Ecological diversification in the Bacillus cereus Group. Environ Microbiol 10(4): 851-865.
  27. Scherer S. und M. Ehling-Schulz. (2008). Riesiges Genreservoir eines Krankheitserregers. Spektrum der Wissenschaften, 04/08, 14-16.
  28. Serra, D. O., Lucking, G., Weiland, F., Schulz, S., Gorg, A., Yantorno, O. M. and Ehling-Schulz, M. (2008). Proteome approaches combined with Fourier transform infrared spectroscopy revealed a distinctive biofilm physiology in Bordetella pertussis. Proteomics 8(23-24): 4995-5010.
  29. Fricker, M., Messelhausser, U., Busch, U., Scherer, S. and Ehling-Schulz, M. (2007). Diagnostic real-time PCR assays for the detection of emetic Bacillus cereus strains in foods and recent food-borne outbreaks. Appl Environ Microbiol 73(6): 1892-1898.
  30. Messelhäusser, U., Fricker, M., Ehling-Schulz, M., Ziegler, H., Elmer-Englhard, D., Kleih, W. u. and Busch, U. (2007). Real-time-PCR-System zum Nachweis von Bacillus cereus (emetischer Typ) in Lebensmitteln. Journal für Verbraucherschutz und Lebensmittelsicherheit 2(2): 190-193.
  31. Carlin, F., Fricker, M., Pielaat, A., Heisterkamp, S., Shaheen, R., Salonen, M. S., Svensson, B., Nguyen-the, C. and Ehling-Schulz, M. (2006). Emetic toxin-producing strains of Bacillus cereus show distinct characteristics within the Bacillus cereus group. Int J Food Microbiol 109(1-2): 132-138.
  32. Ehling-Schulz, M., Fricker, M., Grallert, H., Rieck, P., Wagner, M. and Scherer, S. (2006). Cereulide synthetase gene cluster from emetic Bacillus cereus: structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1. BMC Microbiol 6: 20.
  33. Ehling-Schulz, M., Guinebretiere, M. H., Monthan, A., Berge, O., Fricker, M. and Svensson, B. (2006). Toxin gene profiling of enterotoxic and emetic Bacillus cereus. FEMS Microbiol Lett 260(2): 232-240.
  34. Magarvey, N. A., Ehling-Schulz, M. and Walsh, C. T. (2006). Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line. J Am Chem Soc 128(33): 10698-10699.
  35. Mayr, R., Busse, H. J., Worliczek, H. L., Ehling-Schulz, M. and Scherer, S. (2006). Ornithinibacillus gen. nov., with the species Ornithinibacillus bavariensis sp. nov. and Ornithinibacillus californiensis sp. nov. Int J Syst Evol Microbiol 56(Pt 6): 1383-1389.
  36. Shaheen, R., Andersson, M. A., Apetroaie, C., Schulz, A., Ehling-Schulz, M., Ollilainen, V. M. and Salkinoja-Salonen, M. S. (2006). Potential of selected infant food formulas for production of Bacillus cereus emetic toxin, cereulide. Int J Food Microbiol 107(3): 287-294.
  37. Ehling-Schulz, M., Vukov, N., Schulz, A., Shaheen, R., Andersson, M., Martlbauer, E. and Scherer, S. (2005). Identification and partial characterization of the nonribosomal peptide synthetase gene responsible for cereulide production in emetic Bacillus cereus. Appl Environ Microbiol 71(1): 105-113.
  38. Ehling-Schulz, M., Svensson, B., Guinebretiere, M. H., Lindback, T., Andersson, M., Schulz, A., Fricker, M., Christiansson, A., Granum, P. E., Martlbauer, E., Nguyen-The, C., Salkinoja-Salonen, M. and Scherer, S. (2005). Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains. Microbiology 151(Pt 1): 183-197.
1 Protocol published
Authors:  Elrike Frenzel and Monika Ehling-Schulz, date: 01/20/2013, view: 11189, Q&A: 0
The emetic subgroup of Bacillus cereus strains produces cereulide, a dodecadepsipeptide (1.2 kDa), which is the causative agent of food poisonings. Cereulide is synthesized by a nonribosomal peptide synthetase (NRPS), the Ces-NRPS ...
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