一琳 邰 1 protocol

玥 应 1 protocol

晓阳 吴 1 protocol

锦云 吴 1 protocol
Abhijit Kale Deciduous Therapeutics
9 protocols

Ehsan Kheradpezhouh Australian National University
17 protocols

Geoffrey Lau City University of Hong Kong
18 protocols

Narayan Subramanian Florida State University
5 protocols

Miao He
  • Faculty, Institute of Brain Science, Fudan University
Research focus
  • Neuroscience
  • Neuronal diversity
    Genetic targeting
    Neural circuit
  • 4 Author merit


Ph.D, Stony Brook University, 2011

Lab information

Miao He Lab


1. Zhu T, Zhao Y, Zhang P, Shao Y, He J, Xue P, Zheng W, Qu W, Jia X, Zhou Z, Lu R, He M, Zhang Y*. Lead impairs the development of innate lymphoid cells by impeding the differentiation of their progenitors.Toxicol Sci. 2020 May 19:kfaa074. doi: 10.1093/toxsci/kfaa074. Online ahead of print. PMID: 32428222
2. Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z*, Chen B*. Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Rep. 2020 Mar 31;30(13):4490-4504.e4.
3. Cong W, Shi Y, Qi Y, Wu J, Gong L, He M*. Viral approaches to study the mammalian brain: Lineage tracing, circuit dissection and therapeutic applications. J Neurosci Methods. 2020 Apr 1;335:108629.
4. Qiu F., Mao X., Liu P., Wu J., Zhang Y., Sun D., Zhu Y., Gong L., Shao M., Fan K., Chen J., Lu J., Jiang Y., Zhang Y., Curia G., Li A., He M*. microRNA deficiency in VIP+ interneurons leads to cortical circuit dysfunction. Cerebral Cortex 2019 (Advance online publication)
5. Chen, Z. K., Yuan, X. S., Dong, H., Wu, Y. F., Chen, G. H., He, M., Qu, W. M., and Huang, Z. L., Whole-Brain Neural Connectivity to Lateral Pontine Tegmentum GABAergic Neurons in Mice. Front Neurosci, 2019. 13: p. 375.
6. Xu H, Liu L, Tian Y, Wang J, Li J, Zheng J, Zhao H, He M, Xu TL, Duan S, Xu H.A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex. Neuron. 2019 May 8;102(3):668-682.e5.
7. Yang, Z., Zhao, Y., Li, Q., Shao, Y., Yu, X., Cong, W., Jia, X., Qu, W., Cheng, L., Xue, P., Zhou, Z., He, M., and Zhang, Y., Developmental exposure to mercury chloride impairs social behavior in male offspring dependent on genetic background and maternal autoimmune environment. Toxicology and Applied Pharmacology, 2019. 370: p. 1-13.
8. Cai Z., Wang G., Chen Y. and He M.. Caesarean Sectioning and Cross-Fostering of the Mouse . Bio-protocol Bio101 2018 e3085. DOI: 10.21769/BioProtoc.3085.
9. Li, J., Wang C., Zhang Z., Wen Y., An L., Liang Q., Xu Z., Wei S., Li W., Guo T., Liu G., Tao G., You Y., Du H., Fu Z., He M., Chen B., Campbell K., Alvarez-Buylla A., Rubenstein J. L., Yang Z. Transcription factors sp8 and sp9 coordinately regulate olfactory bulb interneuron development. Cereb Cortex 2018 Sep 1;28(9):3278-3294. doi: 10.1093/cercor/bhx199.
10. Kelly SM, Raudales R, He M, Lee JH, Kim Y, Gibb LG, Wu P, Matho K, Osten P, Graybiel AM, Huang ZJ. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018 Jul 25;99(2):345-361.e4.
11. Luo SX, Huang J, Li Q, Mohammad H, Lee CY, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science. 2018 Jul 6;361(6397):76-81.
12. Zhao Y, Li Q, Yang Z, Shao Y, Xue P, Qu W, Jia X, Cheng L, He M, He R, Zhou Z, Zhang Y.Cadmium activates non-canonical Wnt signaling to impair hematopoietic stem cell function in mice. Toxicol Sci. 2018 Jun 25.
13. Li Q, Yang Z, Zhang P, Zhao Y, Yu X, Xue P, Shao Y, Li Q, Jia X, Zhang Q, Cheng L, He M, Zhou Z, Zhang Y. Mercury impact on hematopoietic stem cells is regulated by IFNγ-dependent bone marrow-resident macrophages in mice. Toxicol Lett. 2018 May 31;295:54-63.
14. He, M., Huang, ZJ. Genetic approaches to access cell types in mammalian nervous systems. Curr Opin Neurobiol. 2018 Jun;50:109-118. doi: 10.1016/j.conb.2018.02.003
15. Schiff, H.C., Bouhuis, A.,Yu, K., Penzo, M.A., Li, H., He, M., Li, B. An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior., J Neurosci., 2018.2.7, 38(6): 1418~1429
16. Yu, K., Ahrens S., Zhang X., Schiff H., Ramakrishnan C., Fenno L., Deisseroth K., Zhao F., Luo M. H., Gong L., He M., Zhou P., Paninski L., Li B. The central amygdala controls learning in the lateral amygdala. Nat Neurosci 2017; 20(12): 1680-1685.
17. Paul, A., Crow M., Raudales R., He M., Gillis J., Huang Z. J. Transcriptional architecture of synaptic communication delineates GABAergic neuron identity. Cell 2017; 171(3): 522-539 e520.
18. Kim, Y., Yang G. R., Pradhan K., Venkataraju K. U., Bota M., Garcia Del Molino L. C., Fitzgerald G., Ram K., He M., Levine J. M., Mitra P., Huang Z. J., Wang X. J., Osten P. Brain-wide maps reveal stereotyped cell-type-based cortical architecture and subcortical sexual dimorphism. Cell 2017; 171(2): 456-469 e422.
19. Lu, J., Tucciarone J., Padilla-Coreano N., He M., Gordon J. A., Huang Z. J. Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. Nat Neurosci 2017; 20(10): 1377-1383.
20. Li, Q., Zhang P., Yu X., Zhao Y., Li Q., Zhang Y., Yang Z., Xie Y., Xue P., Sun S., Jia X., Zhou Z., He M., Zhang Y. Lead transiently promotes granulocyte-macrophage progenitor differentiation and subsequently suppresses common myeloid progenitor differentiation. Toxicol Sci 2017.
21. He M., Tucciarone J., Lee S., Nigro M. J., Kim Y., Levine J. M., Kelly S. M., Krugikov I., Wu P., Chen Y., Gong L., Hou Y., Osten P., Rudy B., Huang Z. J. Strategies and tools for combinatorial targeting of GABAergic neurons in mouse cerebral cortex. Neuron 2016; 91(6): 1228-1243.
22. Zhang, Q., Zhang Y., Wang C., Xu Z., Liang Q., An L., Li J., Liu Z., You Y., He M., Mao Y., Chen B., Xiong Z. Q., Rubenstein J. L., Yang Z. The zinc finger transcription factor sp9 is required for the development of striatopallidal projection neurons. Cell Rep 2016; 16(5): 1431-1444.
23. Penzo M.A., Robert V., Tucciarone J., De Bundel D., Wang M., Van Aelst L., Darvas M., Parada L.F., Palmiter R.D., He M., Huang Z.J., Li B. The paraventricular thalamus controls a central amygdala fear circuit. Nature 2015; 519, 455-459.
24. Zhou, X., Liu F., Tian M., Xu Z., Liang Q., Wang C., Li J., Liu Z., Tang K., He M., Yang Z. Transcription factors coup-tfi and coup-tfii are required for the production of granule cells in the mouse olfactory bulb. Development 2015; 142(9): 1593-1605.
25. Ahrens S., Jaramillo S., Yu K., Ghosh S., Hwang G.R., Paik R., Lai C., He M., Huang Z.J., and Li B. ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nat Neurosci 2015; 18, 104-111.
26. Fenno, L. E., Mattis J., Ramakrishnan C., Hyun M., Lee S. Y., He M., Tucciarone J., Selimbeyoglu A., Berndt A., Grosenick L., Zalocusky K. A., Bernstein H., Swanson H., Perry C., Diester I., Boyce F. M., Bass C. E., Neve R., Huang Z. J., Deisseroth K. Targeting cells with single vectors using multiple-feature boolean logic. Nat Methods 2014; 11(7): 763-772.
27. Huang, Z. J., Taniguchi H., He M., Kuhlman S. Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain. Cold Spring Harb Protoc 2014; 2014(2): 190-194.
28. Huang, Z. J., Taniguchi H., He M., Kuhlman S. Genetic labeling of neurons in mouse brain. Cold Spring Harb Protoc 2014; 2014(2): 150-160.
29. Pfeffer, C. K., Xue M., He M., Huang Z. J., Scanziani M. Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons. Nat Neurosci 2013; 16(8): 1068-1076.
30. He, M., Liu Y., Wang X., Zhang M. Q., Hannon G. J., Huang Z. J. Cell-type-based analysis of microrna profiles in the mouse brain. Neuron 2012; 73(1): 35-48.
31. Taniguchi, H., He M., Wu P., Kim S., Paik R., Sugino K., Kvitsiani D., Fu Y., Lu J., Lin Y., Miyoshi G., Shima Y., Fishell G., Nelson S. B., Huang Z. J. A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 2011; 71(6): 995-1013.
32. Qin, B., He M., Chen X., Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem 2006; 281(48): 36891-36896.
33. Huang Z.J., Taniquchi H., He M., Kuhlman S. (2011). Chapter 13: Genetic Labeling of Neurons in Mouse Brain. Imaging in Developmental Biology: A Laboratory Manual (Book chapter)
34. He, M., Shanghai Jiaotong University Press (IBSN: 9787313227782), Book Translation(English to Chinese) Innate: How the Wiring of Our Brains Shapes Who We Are by Kevin J. Mitchell, 2018, Princeton University Press (ISBN: 9780691173887) 304 pages
4 Protocols published
Authors:  蔡哲平 , 王国宏 , 陈扬 and 何苗, date: 09/13/2018, view: 4008, Q&A: 0
2 Protocols reviewed
Staining and Quantitative Analysis of Myelinating Oligodendrocytes in the Mouse Grey Matter
Authors:  Matthew Swire and Charles ffrench-Constant, date: 10/20/2020, view: 231, Q&A: 0
Oligodendrocytes generate distinct patterns of myelination throughout the CNS. Variations in myelination along axons may enable neurons to fine-tune conduction velocities and alter signal synchronisation. Here we outline a staining protocol ...
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Induction of Photothrombotic Stroke in the Sensorimotor Cortex of Rats and Preparation of Tissue for Analysis of Stroke Volume and Topographical Cortical Localization of Ischemic Infarct
Authors:  Anna M. Wiersma and Ian R. Winship, date: 05/20/2018, view: 7214, Q&A: 0
The photothrombotic model of stroke is commonly used in research as it allows the ischemic infarct to be targeted to specific regions of the cortex with high reproducibility and well-defined infarct borders. Unlike other models of stroke, ...
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7 Protocols edited
Precise Targeting of Single Microelectrodes to Orientation Pinwheel Centers
Authors:  Xue Mei Song, Ming Li, Tao Xu, Dewen Hu and Anna Wang Roe, date: 06/05/2020, view: 658, Q&A: 0
In the mammalian visual system, early stages of visual form perception begin with orientation selective neurons in primary visual cortex (V1). In many species (including humans, monkeys, tree shrews, cats, and ferrets), these neurons are organized ...
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Preparation of a Bacteriophage T4-based Prokaryotic-eukaryotic Hybrid Viral Vector for Delivery of Large Cargos of Genes and Proteins into Human Cells
Authors:  Jingen Zhu, Pan Tao, Marthandan Mahalingam and Venigalla B. Rao, date: 04/05/2020, view: 917, Q&A: 0
A viral vector that can safely and efficiently deliver large and diverse molecular cargos into cells is the holy grail of curing many human diseases. Adeno-associated virus (AAV) has been extensively used but has a very small capacity. The ...
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