Eliane Hajnsdorf
  • Institut de Biolgie PhysicoChimique, CNRS FRE3630 (previously UPR9073), France
Research focus
  • Microbiology
  • 1 Author merit

Current position

CNRS Director of Research at the Institut de Biologie Physico-Chimique in Paris, France. Her research focuses on RNA metabolism and gene regulation in Escherichia coli

Publications (since 2000)

  1. Hajnsdorf, E.* and Boni, I. V.* (2012). Multiple activities of RNA-binding proteins S1 and Hfq. Biochimie 94(7): 1544-1553.(*Corresponding authors)
  2. Maes, A., Gracia, C., Hajnsdorf, E.* and Regnier, P.* (2012). Search for poly(A) polymerase targets in E. coli reveals its implication in surveillance of Glu tRNA processing and degradation of stable RNAs. Mol Microbiol 83(2): 436-451.(*Corresponding authors)
  3. Busi, F., Le Derout, J., Cerciat, M., Regnier, P. and Hajnsdorf, E. (2010). Is the secondary putative RNA-RNA interaction site relevant to GcvB mediated regulation of oppA mRNA in Escherichia coli? Biochimie 92(10): 1458-1461.
  4. Le Derout, J., Boni, I. V., Regnier, P. and Hajnsdorf, E. (2010). Hfq affects mRNA levels independently of degradation. BMC Mol Biol 11: 17.
  5. Andrade, J. M., Hajnsdorf, E., Regnier, P. and Arraiano, C. M. (2009). The poly(A)-dependent degradation pathway of rpsO mRNA is primarily mediated by RNase R. RNA 15(2): 316-326.
  6. Regnier, P. and Hajnsdorf, E. (2009). Poly(A)-assisted RNA decay and modulators of RNA stability. Prog Mol Biol Transl Sci 85: 137-185.
  7. Reichenbach, B., Maes, A., Kalamorz, F., Hajnsdorf, E. and Gorke, B. (2008). The small RNA GlmY acts upstream of the sRNA GlmZ in the activation of glmS expression and is subject to regulation by polyadenylation in Escherichia coli. Nucleic Acids Res 36(8): 2570-2580.
  8. Regnier, P. and Hajnsdorf, E. (2008). The role of RNA chaperone Hfq in poly(A) metabolism methods to determine positions, abundance, and lengths of short oligo(A) tails. Methods Enzymol 447: 161-181.
  9. Scheibe, M., Bonin, S., Hajnsdorf, E., Betat, H. and Morl, M. (2007). Hfq stimulates the activity of the CCA-adding enzyme. BMC Mol Biol 8: 92.
  10. Joanny, G., Le Derout, J., Brechemier-Baey, D., Labas, V., Vinh, J., Regnier, P. and Hajnsdorf, E. (2007). Polyadenylation of a functional mRNA controls gene expression in Escherichia coli. Nucleic Acids Res 35(8): 2494-2502.
  11. Ziolkowska, K., Derreumaux, P., Folichon, M., Pellegrini, O., Regnier, P., Boni, I. V. and Hajnsdorf, E. (2006). Hfq variant with altered RNA binding functions. Nucleic Acids Res 34(2): 709-720.
  12. Folichon, M., Marujo, P. E., Arluison, V., Le Derout, J., Pellegrini, O., Hajnsdorf, E. and Regnier, P. (2005). Fate of mRNA extremities generated by intrinsic termination: detailed analysis of reactions catalyzed by ribonuclease II and poly(A) polymerase. Biochimie 87(9-10): 819-826.
  13. Bardey, V., Vallet, C., Robas, N., Charpentier, B., Thouvenot, B., Mougin, A., Hajnsdorf, E., Regnier, P., Springer, M. and Branlant, C. (2005). Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli. Mol Microbiol 57(5): 1265-1287.
  14. Folichon, M., Allemand, F., Regnier, P. and Hajnsdorf, E. (2005). Stimulation of poly(A) synthesis by Escherichia coli poly(A)polymerase I is correlated with Hfq binding to poly(A) tails. FEBS J 272(2): 454-463.
  15. Arluison, V., Folichon, M., Marco, S., Derreumaux, P., Pellegrini, O., Seguin, J., Hajnsdorf, E. and Regnier, P. (2004). The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer. Eur J Biochem 271(7): 1258-1265.
  16. Folichon, M., Arluison, V., Pellegrini, O., Huntzinger, E., Regnier, P. and Hajnsdorf, E. (2003). The poly(A) binding protein Hfq protects RNA from RNase E and exoribonucleolytic degradation. Nucleic Acids Res 31(24): 7302-7310.
  17. Le Derout, J., Folichon, M., Briani, F., Deho, G., Regnier, P. and Hajnsdorf, E. (2003). Hfq affects the length and the frequency of short oligo(A) tails at the 3' end of Escherichia coli rpsO mRNAs. Nucleic Acids Res 31(14): 4017-4023.
  18. Arluison, V., Derreumaux, P., Allemand, F., Folichon, M., Hajnsdorf, E. and Regnier, P. (2002). Structural Modelling of the Sm-like Protein Hfq from Escherichia coli. J Mol Biol 320(4): 705-712.
  19. Le Derout, J., Regnier, P. and Hajnsdorf, E. (2002). Both temperature and medium composition regulate RNase E processing efficiency of the rpsO mRNA coding for ribosomal protein S15 of Escherichia coli. J Mol Biol 319(2): 341-349.
  20. Briani, F., Del Vecchio, E., Migliorini, D., Hajnsdorf, E., Regnier, P., Ghisotti, D. and Deho, G. (2002). RNase E and polyadenyl polymerase I are involved in maturation of CI RNA, the P4 phage immunity factor. J Mol Biol 318(2): 321-331.
  21. Marujo, P. E., Hajnsdorf, E., Le Derout, J., Andrade, R., Arraiano, C. M. and Regnier, P. (2000). RNase II removes the oligo(A) tails that destabilize the rpsO mRNA of Escherichia coli. RNA 6(8): 1185-1193
  22. Hajnsdorf, E. and Regnier, P. (2000). Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I. Proc Natl Acad Sci U S A 97(4): 1501-1505.
1 Protocol published
Polyadenylated RNA Sampling
Author:  Eliane Hajnsdorf, date: 09/05/2012, view: 9184, Q&A: 0
Polyadenylation is a post-transcriptional modification of RNA occurring in prokaryotes, eukaryotes and organelles. However, the function and extent of bacterial polyadenylation are in marked contrast to those of eukaryotic poly(A) tails. In fact, ...
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