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Reviewer
Manuel E. Lopez
  • Stanford University
Research focus
  • Neuroscience
  • 2 Author merit

Education

Ph.D. in Developmental Biology, Stanford University, 2011

Current position

Industry Postdoc, NGM Biopharmaceuticals, South San Francisco, CA (2013-current)
Background: Neurodegenerative and metabolic disease; neural bases of behavior; lysosome/endosome trafficking and lipid cell biology

Publications

  1. Lopez, M. E. and Scott, M. P. (2013). Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C. Dis Model Mech 6(5): 1089-1100.
  2. Lopez, M. E., Klein, A. D. and Scott, M. P. (2012). Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation 9: 216.
  3. Lopez, M. E., Klein, A. D., Hong, J., Dimbil, U. J. and Scott, M. P. (2012). Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet 21(13): 2946-2960.
    Cover of Human Molecular Genetics 2012, 21(13)
  4. Lopez, M. E., Klein, A. D., Dimbil, U. J. and Scott, M. P. (2011). Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci 31(12): 4367-4378.
    Featured article in This Week In the Journal ( TWIJ), Neurobiology of Disease, The Journal of Neuroscience, 31(12):i-i
  5. Voronina, E., Lopez, M., Juliano, C. E., Gustafson, E., Song, J. L., Extavour, C., George, S., Oliveri, P., McClay, D. and Wessel, G. (2008). Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development. Dev Biol 314(2): 276-286.
2 Protocols published
Combined in situ Hybridization/Immunohistochemistry (ISH/IH) on Free-floating Vibratome Tissue Sections
Author:  Manuel E. Lopez, date: 09/20/2014, view: 7448, Q&A: 0
In situ hybridization and immunostaining are common techniques for localizing gene expression, the mRNA and protein respectively, within tissues. Both techniques can be applied to tissue sections to achieve similar goals, but in some cases, ...
A Quick, No Frills Approach to Mouse Genotyping
Author:  Manuel E. Lopez, date: 08/05/2012, view: 16176, Q&A: 1
Mice are extremely powerful mammalian genetic model organisms for basic and medical research, but managing a colony of transgenic mice is time consuming and expensive, many times requiring the help of dedicated technicians. Slow and laborious ...