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Coauthors
Oliver Mühlemann Department of Chemistry and Biochemistry, University of Bern, Switzerland
2 protocols

David Zünd
  • Department of Chemistry and Biochemistry, University of Bern, Switzerland
  • 2 Author merit

Education

M.S. in Biochemistry, University of Bern, Switzerland, 2010

Current position

Ph.D. student at the University of Bern, Switzerland (2010-present)

Publications

  1. Zünd, D., and Mühlemann, O. (2013). Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation. Translation 1:e26997.
  2. Zünd, D., Grüber, A. R., Zavolan, M. and Mühlemann, O. (2013). Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat Struct Mol Biol 20(8): 936-943.
  3. Schweingruber, C., Rufener, S. C., Zünd, D., Yamashita, A. and Mühlemann, O. (2013). Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells. Biochim Biophys Acta 1829(6-7): 612-623.
2 Protocols published
UPF1 RNA Immunoprecipitation from Mini-μ Construct–expressing Cells
Authors:  David Zünd and Oliver Mühlemann, date: 04/05/2014, view: 4601, Q&A: 0
UPF1, an RNA helicase and a core factor of nonsense-mediated mRNA decay (NMD), interacts with RNA independently of the sequence context. To investigate the influence of translation on the association of UPF1 with specific reporter transcripts, UPF1 ...
Individual-nucleotide-resolution UV Cross-linking and Immunoprecipitation (iCLIP) of UPF1
Authors:  David Zünd and Oliver Mühlemann, date: 04/05/2014, view: 7056, Q&A: 0
The fate of mRNA, in particular its stability, localization and rate of translation is regulated by RNA binding proteins assembling to messenger ribonucleoprotein (mRNP) complexes. To investigate the transcriptome-wide RNA binding sites of UPF1, the ...