Improve Research Reproducibility A Bio-protocol resource
CN

AN
Angel R. Nebreda
  • Institute for Research in Biomedicine (IRB Barcelona), Spain
Research fields
  • Cell biology
Personal information

Education

Ph.D. in Microbiology/Molecular Biology, University of Salamanca, 1986

Current position

ICREA Research Professor at the Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain

Publications (since 2007)

  1. Gupta, J., del Barco Barrantes, I., Igea, A., Sakellariou, S., Pateras, I. S., Gorgoulis, V. G. and Nebreda, A. R. (2014). Dual function of p38alpha MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 25(4): 484-500.
  2. Urosevic, J., Garcia-Albeniz, X., Planet, E., Real, S., Cespedes, M. V., Guiu, M., Fernandez, E., Bellmunt, A., Gawrzak, S., Pavlovic, M., Mangues, R., Dolado, I., Barriga, F. M., Nadal, C., Kemeny, N., Batlle, E., Nebreda, A. R. and Gomis, R. R. (2014). Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH. Nat Cell Biol 16(7): 685-694.
  3. Urosevic, J., Nebreda, A. R. and Gomis, R. R. (2014). MAPK signaling control of colon cancer metastasis. Cell Cycle 13(17): 2641-2642.
  4. Trempolec, N., Dave-Coll, N. and Nebreda, A. R. (2013). SnapShot: p38 MAPK signaling. Cell 152(3): 656-656 e651.
  5. Perez, Y., Maffei, M., Igea, A., Amata, I., Gairi, M., Nebreda, A. R., Bernado, P. and Pons, M. (2013). Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism. Sci Rep 3: 1295.
  6. Trempolec, N., Dave-Coll, N. and Nebreda, A. R. (2013). SnapShot: p38 MAPK substrates. Cell 152(4): 924-924 e921.
  7. Tormos, A. M., Arduini, A., Talens-Visconti, R., del Barco Barrantes, I., Nebreda, A. R. and Sastre, J. (2013). Liver-specific p38alpha deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice. Hepatology 57(5): 1950-1961.
  8. Amata, I., Maffei, M., Igea, A., Gay, M., Vilaseca, M., Nebreda, A. R. and Pons, M. (2013). Multi-phosphorylation of the intrinsically disordered unique domain of c-Src studied by in-cell and real-time NMR spectroscopy. Chembiochem 14(14): 1820-1827.
  9. Tormos, A. M., Talens-Visconti, R., Nebreda, A. R. and Sastre, J. (2013). p38 MAPK: a dual role in hepatocyte proliferation through reactive oxygen species. Free Radic Res 47(11): 905-916.
  10. Pereira, L., Igea, A., Canovas, B., Dolado, I. and Nebreda, A. R. (2013). Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK. EMBO Mol Med 5(11): 1759-1774.
  11. Ho, K. K., McGuire, V. A., Koo, C. Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. and Lam, E. W. (2012). Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem 287(2): 1545-1555.
  12. Joaquin, M., Gubern, A., Gonzalez-Nunez, D., Josue Ruiz, E., Ferreiro, I., de Nadal, E., Nebreda, A. R. and Posas, F. (2012). The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J 31(13): 2952-2964.
  13. Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. and Kapur, R. (2012). Genetic evidence for critical roles of P38alpha protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem 287(24): 20258-20269.
  14. Furlan, A., Lamballe, F., Stagni, V., Hussain, A., Richelme, S., Prodosmo, A., Moumen, A., Brun, C., Del Barco Barrantes, I., Arthur, J. S., Koleske, A. J., Nebreda, A. R., Barila, D. and Maina, F. (2012). Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. J Hepatol 57(6): 1292-1298.
  15. Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. and Kapur, R. (2012). p38alpha protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem 287(40): 33215-33226.
  16. Llopis, A., Salvador, N., Ercilla, A., Guaita-Esteruelas, S., Barrantes Idel, B., Gupta, J., Gaestel, M., Davis, R. J., Nebreda, A. R. and Agell, N. (2012). The stress-activated protein kinases p38alpha/beta and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Cell Cycle 11(19): 3627-3637.
  17. Warr, N., Carre, G. A., Siggers, P., Faleato, J. V., Brixey, R., Pope, M., Bogani, D., Childers, M., Wells, S., Scudamore, C. L., Tedesco, M., del Barco Barrantes, I., Nebreda, A. R., Trainor, P. A. and Greenfield, A. (2012). Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell 23(5): 1020-1031.
  18. Barry, A. O., Boucherit, N., Mottola, G., Vadovic, P., Trouplin, V., Soubeyran, P., Capo, C., Bonatti, S., Nebreda, A., Toman, R., Lemichez, E., Mege, J. L. and Ghigo, E. (2012). Impaired stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes. Cell Host Microbe 12(6): 751-763.
  19. del Barco Barrantes, I. and Nebreda, A. R. (2012). Roles of p38 MAPKs in invasion and metastasis. Biochem Soc Trans 40(1): 79-84.
  20. Ronkina, N., Menon, M. B., Schwermann, J., Arthur, J. S., Legault, H., Telliez, J. B., Kayyali, U. S., Nebreda, A. R., Kotlyarov, A. and Gaestel, M. (2011). Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res 39(7): 2503-2518.
  21. Swat, A., Dolado, I., Igea, A., Gomez-Lopez, G., Pisano, D. G., Cuadrado, A. and Nebreda, A. R. (2011). Expression and functional validation of new p38alpha transcriptional targets in tumorigenesis. Biochem J 434(3): 549-558.
  22. del Barco Barrantes, I., Coya, J. M., Maina, F., Arthur, J. S. and Nebreda, A. R. (2011). Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A 108(31): 12764-12769.
  23. Ruiz, E. J., Vilar, M. and Nebreda, A. R. (2010). A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry. Curr Biol 20(8): 717-723.
  24. Lemaire, M., Ducommun, B. and Nebreda, A. R. (2010). UV-induced downregulation of the CDC25B protein in human cells. FEBS Lett 584(6): 1199-1204.
  25. Ferreiro, I., Joaquin, M., Islam, A., Gomez-Lopez, G., Barragan, M., Lombardia, L., Dominguez, O., Pisano, D. G., Lopez-Bigas, N., Nebreda, A. R. and Posas, F. (2010). Whole genome analysis of p38 SAPK-mediated gene expression upon stress. BMC Genomics 11: 144.
  26. Santamaria, P. G. and Nebreda, A. R. (2010). Deconstructing ERK signaling in tumorigenesis. Mol Cell 38(1): 3-5.
  27. Cuadrado, A., Corrado, N., Perdiguero, E., Lafarga, V., Munoz-Canoves, P. and Nebreda, A. R. (2010). Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J 29(12): 2014-2025.
  28. Mouron, S., de Carcer, G., Seco, E., Fernandez-Miranda, G., Malumbres, M. and Nebreda, A. R. (2010). RINGO C is required to sustain the spindle-assembly checkpoint. J Cell Sci 123(Pt 15): 2586-2595.
  29. Cuadrado, A. and Nebreda, A. R. (2010). Mechanisms and functions of p38 MAPK signalling. Biochem J 429(3): 403-417.
  30. Cuenda, A. and Nebreda, A. R. (2009). p38delta and PKD1: kinase switches for insulin secretion. Cell 136(2): 209-210.
  31. Swat, A., Dolado, I., Rojas, J. M. and Nebreda, A. R. (2009). Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation. Mol Cell Biol 29(12): 3332-3343.
  32. Git, A., Allison, R., Perdiguero, E., Nebreda, A. R., Houliston, E. and Standart, N. (2009). Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes. RNA 15(6): 1121-1133.
  33. Lafarga, V., Cuadrado, A., Lopez de Silanes, I., Bengoechea, R., Fernandez-Capetillo, O. and Nebreda, A. R. (2009). p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol 29(16): 4341-4351.
  34. Wagner, E. F. and Nebreda, A. R. (2009). Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9(8): 537-549.
  35. Dinarina, A., Santamaria, P. G. and Nebreda, A. R. (2009). Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A. FEBS Lett 583(17): 2772-2778.
  36. Cuadrado, M., Gutierrez-Martinez, P., Swat, A., Nebreda, A. R. and Fernandez-Capetillo, O. (2009). p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage. Cancer Res 69(22): 8726-8732.
  37. Dolado, I. and Nebreda, A. R. (2008). Regulation of tumorigenesis by p38α MAP kinase. In: Stress-Activated Protein Kinases. Springer: 99-128.
  38. Dinarina, A., Ruiz, E. J., O'Loghlen, A., Mouron, S., Perez, L. and Nebreda, A. R. (2008). Negative regulation of cell-cycle progression by RINGO/Speedy E. Biochem J 410(3): 535-542.
  39. Hernandez-Torres, F., Martinez-Fernandez, S., Zuluaga, S., Nebreda, A., Porras, A., Aranega, A. E. and Navarro, F. (2008). A role for p38alpha mitogen-activated protein kinase in embryonic cardiac differentiation. FEBS Lett 582(7): 1025-1031.
  40. Jagemann, L. R., Perez-Rivas, L. G., Ruiz, E. J., Ranea, J. A., Sanchez-Jimenez, F., Nebreda, A. R., Alba, E. and Lozano, J. (2008). The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner. J Biol Chem 283(25): 17450-17462.
  41. Heinrichsdorff, J., Luedde, T., Perdiguero, E., Nebreda, A. R. and Pasparakis, M. (2008). p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. EMBO Rep 9(10): 1048-1054.
  42. Ruiz, E. J., Hunt, T. and Nebreda, A. R. (2008). Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation. Mol Cell 32(2): 210-220.
  43. Dolado, I. and Nebreda, A. R. (2008). AKT and oxidative stress team up to kill cancer cells. Cancer Cell 14(6): 427-429.
  44. Posas, F. and Nebreda, A. R. (2008). Topics in Current Genetics series featuring review articles by several authors. In: Stress-Activated Protein Kinases (SAPK). Springer, 326.
  45. Dolado, I., Swat, A., Ajenjo, N., De Vita, G., Cuadrado, A. and Nebreda, A. R. (2007). p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11(2): 191-205.
  46. Cuadrado, A., Lafarga, V., Cheung, P. C., Dolado, I., Llanos, S., Cohen, P. and Nebreda, A. R. (2007). A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. EMBO J 26(8): 2115-2126.
  47. Zuluaga, S., Alvarez-Barrientos, A., Gutierrez-Uzquiza, A., Benito, M., Nebreda, A. R. and Porras, A. (2007). Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal 19(1): 62-74.
  48. Ventura, J. J., Tenbaum, S., Perdiguero, E., Huth, M., Guerra, C., Barbacid, M., Pasparakis, M. and Nebreda, A. R. (2007). p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 39(6): 750-758.
  49. Meissner, J. D., Chang, K. C., Kubis, H. P., Nebreda, A. R., Gros, G. and Scheibe, R. J. (2007). The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. J Biol Chem 282(10): 7265-7275.
  50. Zuluaga, S., Gutierrez-Uzquiza, A., Bragado, P., Alvarez-Barrientos, A., Benito, M., Nebreda, A. R. and Porras, A. (2007). p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum. FEBS Lett 581(20): 3819-3825.
  51. Casado-Vela, J., Ruiz, E. J., Nebreda, A. R. and Casal, J. I. (2007). A combination of neutral loss and targeted product ion scanning with two enzymatic digestions facilitates the comprehensive mapping of phosphorylation sites. Proteomics 7(15): 2522-2529.
  52. Lafarga, V., Cuadrado, A. and Nebreda, A. R. (2007). p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents. Cell Cycle 6(19): 2319-2322.
  53. Cuadrado, A. and Nebreda, A. R. (2007). New insights into RSK activation and hematopoietic cancer. Cancer Cell 12(3): 187-189.
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