Education
Ph.D., Molecular Biology, University of California, Berkeley, California, 1967
Current position
Head, Retrovirus Assembly Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD (1999-present)
Publications (since 2010)
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Jensen, S. M., Ruscetti, F. W., Rein, A., Bertolette, D. C., Saucedo, C. J., O'Keefe, B. R. and Jones, K. S. (2014). Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. J Virol 88(4): 2327-2332.
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Munro, J. B., Nath, A., Farber, M., Datta, S. A., Rein, A., Rhoades, E. and Mothes, W. (2014). A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol 88(6): 3577-3585.
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Nair, S., Sanchez-Martinez, S., Ji, X. and Rein, A. (2014). Biochemical and biological studies of mouse APOBEC3. J Virol 88(7): 3850-3860.
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Grohman, J. K., Gorelick, R. J., Kottegoda, S., Allbritton, N. L., Rein, A. and Weeks, K. M. (2014). An immature retroviral RNA genome resembles a kinetically trapped intermediate state. J Virol 88(11): 6061-6068.
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Aloia, A. L., Duffy, L., Pak, V., Lee, K. E., Sanchez-Martinez, S., Derse, D., Heidecker, G., Cornetta, K. and Rein, A. (2013). A reporter system for replication-competent gammaretroviruses: the inGluc-MLV-DERSE assay. Gene Ther 20(2): 169-176.
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O'Carroll, I. P., Soheilian, F., Kamata, A., Nagashima, K. and Rein, A. (2013). Elements in HIV-1 Gag contributing to virus particle assembly. Virus Res 171(2): 341-345.
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Stavrou, S., Nitta, T., Kotla, S., Ha, D., Nagashima, K., Rein, A. R., Fan, H. and Ross, S. R. (2013). Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex. Proc Natl Acad Sci U S A 110(22): 9078-9083.
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Rein, A. (2013). Murine leukemia virus p12 functions include hitchhiking into the nucleus. Proc Natl Acad Sci U S A 110(23): 9195-9196.
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Fang, X., Wang, J., O'Carroll, I. P., Mitchell, M., Zuo, X., Wang, Y., Yu, P., Liu, Y., Rausch, J. W., Dyba, M. A., Kjems, J., Schwieters, C. D., Seifert, S., Winans, R. E., Watts, N. R., Stahl, S. J., Wingfield, P. T., Byrd, R. A.*, Le Grice, S. F., Rein, A. and Wang, Y. X. (2013). An unusual topological structure of the HIV-1 Rev response element. Cell 155(3): 594-605. (*Co-corresponding author)
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O'Carroll, I. P., Crist, R. M., Mirro, J., Harvin, D., Soheilian, F., Kamata, A., Nagashima, K. and Rein, A. (2012). Functional redundancy in HIV-1 viral particle assembly. J Virol 86(23): 12991-12996.
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Sfanos, K. S., Aloia, A. L., De Marzo, A. M. and Rein, A. (2012). XMRV and prostate cancer--a 'final' perspective. Nat Rev Urol 9(2): 111-118.
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Sanchez-Martinez, S., Aloia, A. L., Harvin, D., Mirro, J., Gorelick, R. J., Jern, P., Coffin, J. M. and Rein, A. (2012). Studies on the restriction of murine leukemia viruses by mouse APOBEC3. PLoS One 7(5): e38190.
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Jones, C. P., Datta, S. A., Rein, A., Rouzina, I. and Musier-Forsyth, K. (2011). Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding. J Virol 85(4): 1594-1603.
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Datta, S. A., Temeselew, L. G., Crist, R. M., Soheilian, F., Kamata, A., Mirro, J., Harvin, D., Nagashima, K., Cachau, R. E. and Rein, A. (2011). On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch? J Virol 85(9): 4111-4121.
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Ramalingam, D., Duclair, S., Datta, S. A., Ellington, A., Rein, A. and Prasad, V. R. (2011). RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production. J Virol 85(1): 305-314.
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Datta, S. A., Heinrich, F., Raghunandan, S., Krueger, S., Curtis, J. E., Rein, A. and Nanda, H. (2011). HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid. J Mol Biol 406(2): 205-214.
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Goicochea, N. L., Datta, S. A., Ayaluru, M., Kao, C., Rein, A. and Dragnea, B. (2011). Structure and stoichiometry of template-directed recombinant HIV-1 Gag particles. J Mol Biol 410(4): 667-680.
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Rein, A., Datta, S. A., Jones, C. P. and Musier-Forsyth, K. (2011). Diverse interactions of retroviral Gag proteins with RNAs. Trends Biochem Sci 36(7): 373-380.
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Sfanos, K. S., Aloia, A. L., Hicks, J. L., Esopi, D. M., Steranka, J. P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K. H., Rein, A. and De Marzo, A. M. (2011). Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. PLoS One 6(6): e20874.
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Rein, A. (2011). Murine leukemia viruses: objects and organisms. Advances in virology 2011.
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Datta, S. A., Zuo, X., Clark, P. K., Campbell, S. J., Wang, Y. X. and Rein, A. (2011). Solution properties of murine leukemia virus gag protein: differences from HIV-1 gag. J Virol 85(23): 12733-12741.
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Wu, T., Datta, S. A., Mitra, M., Gorelick, R. J., Rein, A. and Levin, J. G. (2010). Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications. Virology 405(2): 556-567.
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Nanda, H., Datta, S. A., Heinrich, F., Losche, M., Rein, A., Krueger, S. and Curtis, J. E. (2010). Electrostatic interactions and binding orientation of HIV-1 matrix studied by neutron reflectivity. Biophys J 99(8): 2516-2524.
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Gherghe, C., Lombo, T., Leonard, C. W., Datta, S. A., Bess, J. W., Jr., Gorelick, R. J., Rein, A. and Weeks, K. M. (2010). Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proc Natl Acad Sci U S A 107(45): 19248-19253.
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Rein, A. (2010). Nucleic acid chaperone activity of retroviral Gag proteins. RNA Biol 7(6): 700-705.
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Aloia, A. L., Sfanos, K. S., Isaacs, W. B., Zheng, Q., Maldarelli, F., De Marzo, A. M. and Rein, A. (2010). XMRV: a new virus in prostate cancer? Cancer Res 70(24): 10028-10033.