Neuroscience

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    Protocols in Current Issue
    Consummatory Successive Negative Contrast in Rats
    [Abstract] Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and increase oral ethanol consumption in rats. The ...
    Classic Labyrinth Test for Neurobehavioral Evaluation in Wistar Rats
    Author:  Salim Gasmi, date: 09/20/2018, view: 3168, Q&A: 0
    [Abstract] The Classic Labyrinth Test (CLT) is a simple way to evaluate behaviors in rodents such as learning ability, memory, and anxiety. The protocol presented here describes the procedure for use with rats, but the protocol can also be adapted for use in mice if a smaller device is used. In short, the CLT uses a square-shaped maze with a starting point ...
    Evaluating Working Memory on a T-maze in Male Rats
    Authors:  Ahmed M. Hussein, Mekite Bezu and Volker Korz, date: 07/20/2018, view: 5610, Q&A: 0
    [Abstract] Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs–either one-time or through daily injection–can elucidate the underlying mechanisms. The T-maze is especially ...
    The Traveling Salesman Problem (TSP): A Spatial Navigation Task for Rats
    Author:  R. E. Blaser, date: 06/05/2018, view: 2718, Q&A: 0
    [Abstract] The Traveling Salesman Problem (TSP) is a behavioral test used to measure the efficiency of spatial navigation. It is an optimization problem, in which a number of baited targets are placed in an arena, and as the subject travels between the targets, the route is recorded and compared to chance and optimal routes. The TSP is appealing for the ...
    A Rodent Model for Chronic Brain Hypoperfusion Related Diseases: Permanent Bilateral Occlusion of the Common Carotid Arteries (2VO) in Rats
    Authors:  Mei-Ling Yan and Jing Ai, date: 01/05/2018, view: 5265, Q&A: 0
    [Abstract] Permanent occlusion of bilateral common carotid arteries (2VO) in rat is considered as a suitable animal model to mimic chronic brain hypoperfusion status, which is proved to be a risk factor to precede the Alzheimer’s disease or/and vascular dementia. In this protocol, we describe how to successfully ligate the bilateral common carotid arteries ...
    Assessment of Aversion of Acute Pain Stimulus through Conditioned Place Aversion
    [Abstract] Pain is a complex experience. The aversive component of pain has been assessed through conditioned place aversion in rodents. However, this behavioral test does not allow the evaluation of the aversion of an acute pain stimulus. In Zhang et al. (2017), we provide an updated version of a Conditioned Place Aversion paradigm to address this ...
    Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test
    Authors:  Menghon Cheah, James W Fawcett and Melissa R Andrews, date: 08/20/2017, view: 7649, Q&A: 0
    [Abstract] The Hargreaves test is specifically designed to assess thermal pain sensation in rodents such as rats and mice. This test has been used in experiments involving pain sensitization or recovery of thermal pain response following neural injury and regeneration. We present here a step-by-step protocol highlighted with important notes to guide ...
    Locomotor Coordination Assay in Rats
    Authors:  J. Regino Perez-Polo, Harriet C. Rea and Smitha K. Infante, date: 11/20/2015, view: 6266, Q&A: 0
    [Abstract] Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Cell death and brain injury after HI have been shown to cause long-lasting neurological deficits. Two motor coordination tests on rats that had been exposed to HI on postnatal day 7 (P7) showed that HI in the P7 rat is associated with ...
    Creating a Rat Model of Chronic Variate Stress
    Authors:  Rocío M. de Pablos, Manuel Sarmiento and Ana María Espinosa-Oliva, date: 12/05/2014, view: 8745, Q&A: 0
    [Abstract] Stress is a condition of human experience and an important factor in the onset of various diseases. There are numerous studies showing how stress can accelerate cell aging, immune senescence and some age-related diseases such as neurodegenerative disorders and osteoporosis. However, the effects of stress have different consequences depending on ...
    An Experimental Model of Neonatal Nociceptive Stimulation in Rats
    [Abstract] In order to survive, preterm and/or sick neonates need diagnostic and therapeutic measures that may cause discomfort, stress and pain during a critical period of intense growing and modeling of the central nervous system (Anand et al., 2013). Scientific interest in the long lasting effects of the Neonatal Intensive Care (NIC) experience, ...



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