Implanting and Recycling Neuropixels Probes for Recordings in Freely Moving Mice
[Abstract] Recording neural activity in unrestricted animals is necessary to unravel the neural basis of ethological behaviors. Recently, Neuropixels probes have made important strides in improving yield and lowering noise, but have limited use cases in freely moving animals. Although there are a number of studies demonstrating the use of these probes in ...
Displaced Object Recognition Memory in Rats
Authors: Ali N. Mclagan and
Jena B. Hales,
date: 04/20/2019,
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Q&A: 0
[Abstract] The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to ...
A Modified Barnes Maze for Juvenile Rats
[Abstract] To better understand neural codes for spatial navigation and to address cognitive development questions, the neurobiology of postnatal hippocampal development is receiving increased attention. While the Morris Water Maze is the gold standard for assessing hippocampal integrity, potential confounds can be difficult to control for in juvenile ...
Behavioral Evaluation of Odor Memory in Mice
Authors: Afif J. Aqrabawi and
Jun Chul Kim,
date: 09/20/2018,
view: 2506,
Q&A: 0
[Abstract] Behavioural tests based on the spontaneous recognition paradigm have been used extensively for examining the memory capacity of rodents. By exploiting their innate preference to investigate novel stimuli, inferences can be drawn about the perceived familiarity of encountered objects. Olfaction is the dominant sense used by mice to navigate their ...
Classic Labyrinth Test for Neurobehavioral Evaluation in Wistar Rats
Author: Salim Gasmi,
date: 09/20/2018,
view: 2865,
Q&A: 0
[Abstract] The Classic Labyrinth Test (CLT) is a simple way to evaluate behaviors in rodents such as learning ability, memory, and anxiety. The protocol presented here describes the procedure for use with rats, but the protocol can also be adapted for use in mice if a smaller device is used. In short, the CLT uses a square-shaped maze with a starting point ...
Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice
[Abstract] The trace fear conditioning protocol is designed to measure hippocampal function in mice. The protocol includes a neutral conditioned stimulus (tone) and an aversive unconditioned stimulus (shock), separated in time by a trace interval. The trace interval between the tone and the shock critically involves the hippocampus and could be used to ...