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Christelle Breton

Education

Ph.D in Biology, University of Orleans, France in 1984

Current Position

Full Professor at University Grenoble Alpes, France

Publications

  1. Rocha, J., Ciceron, F., de Sanctis, D., Lelimousin, M., Chazalet, V., Lerouxel, O. and Breton, C. (2016). Structure of Arabidopsis thaliana FUT1 Reveals a Variant of the GT-B Class Fold and Provides Insight into Xyloglucan Fucosylation. Plant Cell 28(10): 2352-2364.
  2. Ciceron, F., Rocha, J., Kousar, S., Hansen, S. F., Chazalet, V., Gillon, E., Breton, C. and Lerouxel, O. (2016). Expression, purification and biochemical characterization of AtFUT1, a xyloglucan-specific fucosyltransferase from Arabidopsis thaliana. Biochimie 128-129: 183-192.
  3. Rocha, J., Ciceron, F., Lerouxel, O., Breton, C. and de Sanctis, D. (2016). The galactoside 2-alpha-L-fucosyltransferase FUT1 from Arabidopsis thaliana: crystallization and experimental MAD phasing. Acta Crystallogr F Struct Biol Commun 72(Pt 7): 564-568.
  4. Rocha, J., Sarkis, J., Thomas, A., Pitou, L., Radzimanowski, J., Audry, M., Chazalet, V., de Sanctis, D., Palcic, M. M., Block, M. A., Girard-Egrot, A., Marechal, E. and Breton, C. (2016). Structural insights and membrane binding properties of MGD1, the major galactolipid synthase in plants. Plant J 85(5): 622-633.
  5. Bastien, O., Botella, C., Chevalier, F., Block, M. A., Jouhet, J., Breton, C., Girard-Egrot, A. and Marechal, E. (2016). New Insights on Thylakoid Biogenesis in Plant Cells. Int Rev Cell Mol Biol 323: 1-30.
  6. Perez, S., Sarkar, A., Rivet, A., Breton, C. and Imberty, A. (2015). Glyco3D: a portal for structural glycosciences. Methods Mol Biol 1273: 241-258.
  7. Saliba, M., Ramalanjaona, N., Gulberti, S., Bertin-Jung, I., Thomas, A., Dahbi, S., Lopin-Bon, C., Jacquinet, J. C., Breton, C., Ouzzine, M. and Fournel-Gigleux, S. (2015). Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors. J Biol Chem 290(12): 7658-7670.
  8. Jorgensen, R., Batot, G., Mannerstedt, K., Imberty, A., Breton, C., Hindsgaul, O., Royant, A. and Palcic, M. M. (2014). Structures of a human blood group glycosyltransferase in complex with a photo-activatable UDP-Gal derivative reveal two different binding conformations. Acta Crystallogr F Struct Biol Commun 70(Pt 8): 1015-1021.
  9. Sarkis, J., Rocha, J., Maniti, O., Jouhet, J., Vie, V., Block, M. A., Breton, C., Marechal, E. and Girard-Egrot, A. (2014). The influence of lipids on MGD1 membrane binding highlights novel mechanisms for galactolipid biosynthesis regulation in chloroplasts. FASEB J 28(7): 3114-3123.
  10. Rocha, J., Audry, M., Pesce, G., Chazalet, V., Block, M. A., Marechal, E. and Breton, C. (2013). Revisiting the expression and purification of MGD1, the major galactolipid synthase in Arabidopsis to establish a novel standard for biochemical and structural studies. Biochimie 95(4): 700-708.
  11. Voxeur, A., Andre, A., Breton, C. and Lerouge, P. (2012). Identification of putative rhamnogalacturonan-II specific glycosyltransferases in Arabidopsis using a combination of bioinformatics approaches. PLoS One 7(12): e51129.
  12. Breton, C., Fournel-Gigleux, S. and Palcic, M. M. (2012). Recent structures, evolution and mechanisms of glycosyltransferases. Curr Opin Struct Biol 22(5): 540-549.
  13. Benevides, R. G., Ganne, G., Simoes Rda, C., Schubert, V., Niemietz, M., Unverzagt, C., Chazalet, V., Breton, C., Varrot, A., Cavada, B. S. and Imberty, A. (2012). A lectin from Platypodium elegans with unusual specificity and affinity for asymmetric complex N-glycans. J Biol Chem 287(31): 26352-26364.
  14. Boudiere, L., Botte, C. Y., Saidani, N., Lajoie, M., Marion, J., Brehelin, L., Yamaryo-Botte, Y., Satiat-Jeunemaitre, B., Breton, C., Girard-Egrot, A., Bastien, O., Jouhet, J., Falconet, D., Block, M. A. and Marechal, E. (2012). Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells. Mol Biosyst 8(8): 2023-2035, 2014.
  15. Both, P., Sobczak, L., Breton, C., Hann, S., Nöbauer, K., Paschinger, K., Kozmon, S., Mucha, J. and Wilson, I. B. (2011). Distantly-related plant and nematode core {alpha}1,3-fucosyltransferases display similar trends in structure-function relationships. Glycobiology 21: 1401-1415.
  16. Audry, M., Jeanneau, C., Imberty, A., Harduin-Lepers, A., Delannoy, P. and Breton, C. (2011). Current trends in the structure-activity relationships of sialyltransferases. Glycobiology 21(6): 716-726.
  17. Hansen, S. F., Bettler, E., Rinnan, A., Engelsen, S. B. and Breton, C. (2010). Exploring genomes for glycosyltransferases. Mol Biosyst 6(10): 1773-1781.
  18. Dubots, E., Audry, M., Yamaryo, Y., Bastien, O., Ohta, H., Breton, C., Marechal, E. and Block, M. A. (2010). Activation of the chloroplast monogalactosyldiacylglycerol synthase MGD1 by phosphatidic acid and phosphatidylglycerol. J Biol Chem 285(9): 6003-6011.
  19. Hansen, S. F., Bettler, E., Wimmerova, M., Imberty, A., Lerouxel, O. and Breton, C. (2009). Combination of several bioinformatics approaches for the identification of new putative glycosyltransferases in Arabidopsis. J Proteome Res 8(2): 743-753.
  20. Lescar, J., Sanchez, J. F., Audfray, A., Coll, J. L., Breton, C., Mitchell, E. P. and Imberty, A. (2007). Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin. Glycobiology 17(10): 1077-1083.
  21. Randriantsoa, M., Drouillard, S., Breton, C. and Samain, E. (2007). Synthesis of globopentaose using a novel β1,3-galactosyltransferase activity of the Haemophilus influenzae β1,3-N-acetylgalactosaminyltransferase LgtD. FEBS Letters 581: 2652-2656.
  22. Heissigerova, H., Kocalka, P., Hlavackova, M., Imberty, A., Breton, C., Chazalet, V. and Moravcova, J. (2006). Synthesis of D-galactopyranosylphosphonic and (D-galactopyranosymethyl)phosphonic acids as intermediates of inhibitors of galactosyltransferases. Coll Czec Chem Commun 71: 1659-1672.
  23. Sanchez, J. F., Lescar, J., Chazalet, V., Audfray, A., Gagnon, J., Alvarez, R., Breton, C., Imberty, A. and Mitchell, E. P. (2006). Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold. J Biol Chem 281(29): 20171-20180.
  24. Imberty, A., Wimmerova, M., Koca, J. and Breton, C. (2006). Molecular modelling of glycosyltransferase. Methods Mol Biol. 347:145-156.
  25. Cioci, G., Mitchell, E. P., Chazalet, V., Debray, H., Oscarson, S., Lahmann, M., Gautier, C., Breton, C., Perez, S. and Imberty, A. (2006). Beta-propeller crystal structure of Psathyrella velutina lectin: an integrin-like fungal protein interacting with monosaccharides and calcium. J Mol Biol 357(5): 1575-1591.
  26. Breton, C., Snajdrova, L., Jeanneau, C., Koca, J. and Imberty, A. (2006). Structures and mechanisms of glycosyltransferases. Glycobiology 16(2): 29R-37R.
  27. Botté, C., Jeanneau, C., Snajdrova, L., Bastien, O., Imberty, A., Breton, C. and Maréchal, E. (2005). Molecular modelling and site directed mutagenesis of plant chloroplast MGDG synthase reveal critical residues for activity. J Biol Chem 280: 34691-34701.
Protocols by Christelle Breton
  1. Expression, Purification and Crystallization of Recombinant Arabidopsis Monogalactosyldiacylglycerol Synthase (MGD1)