Education

Master of Science: Fudan University, Shanghai, 2000
Ph.D. in University of Tuebingen, Germany, 2006

Current position

Acting Instructor, Department of Pharmacology, University of Washington, USA

Publications

1. Xiang, Y. Y., Chen, X., Li, J., Wang, S., Faclier, G., Macdonald, J. F., Hogg, J. C., Orser, B. A. and Lu, W. Y. (2013). Isoflurane Regulates Atypical Type-A gamma-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells. Anesthesiology 118(5): 1065-1075.
   
2. Chen, X., Xia, Z. and Storm, D. R. (2012). Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. J Neurosci 32(45): 15769-15778.
   
3. Chen, X., Whissell, P., Orser, B. A. and MacDonald, J. F. (2011). Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS One 6(7): e21970.
   
4. Chen, X., Li, M., Xiong, Z. G., Orser, B. A., Macdonald, J. F. and Lu, W. Y. (2011). An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma. Int J Physiol Pathophysiol Pharmacol 3(4): 249-256.
   
5. Chen, X., Qiu, L., Li, M., Durrnagel, S., Orser, B. A., Xiong, Z. G. and MacDonald, J. F. (2010). Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology 58(7): 1045-1053.
   
6. Chen, X., Numata, T., Li, M., Mori, Y., Orser, B. A., Jackson, M. F., Xiong, Z. G. and MacDonald, J. F. (2010). The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Mol Brain 3: 38.
7. Chen, X., Orser, B. A. and MacDonald, J. F. (2010). Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. Eur J Pharmacol 648(1-3): 15-23.
   
8. Paukert, M., Chen, X., Polleichtner, G., Schindelin, H. and Grunder, S. (2008). Candidate amino acids involved in H⁺ gating of acid-sensing ion channel 1a. J Biol Chem 283(1): 572-581.
   
9. Chen, X., Polleichtner, G., Kadurin, I. and Grunder, S. (2007). Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H⁺. J Biol Chem 282(42): 30406-30413.
   
10. Chen, X. and Grunder, S. (2007). Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J Physiol 579(Pt 3): 657-670.
    
11. Chen, X., Paukert, M., Kadurin, I., Pusch, M. and Grunder, S. (2006). Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium. Neuropharmacology 50(8): 964-974.
    
12. Chen, X., Kalbacher, H. and Grunder, S. (2006). Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent. J Gen Physiol 127(3): 267-276.
    
13. Chen, X., Kalbacher, H. and Grunder, S. (2005). The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H⁺ affinity. J Gen Physiol 126(1): 71-79.