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Calculation of VISTA module score

YZ Yanding Zhao

Last updated date: Mar 15, 2021 Views: 823 Forks: 0

original An abbreviated version of this protocol was published in Science in Jan, 2020
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
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Hi, I have attached the weight profile containing VISTA loss gene signature and the codes for calculation. To reason to perform the Z-transformation is 1)to rescale the data 2)easy to perform the t.test for comparison.

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txt VISTA_module_score_calculation.txt download
txt weight_profile.txt download
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How to cite：
Readers should cite both the Bio-protocol preprint and the original research article where this protocol was used:
  1. Zhao, Y(2021). Calculation of VISTA module score. Bio-protocol Preprint. bio-protocol.org/prep933.
  2. ElTanbouly, M. A., Zhao, Y., Nowak, E., Li, J., Schaafsma, E., Le Mercier, I., Ceeraz, S., Lines, J. L., Peng, C., Carriere, C., Huang, X., Day, M., Koehn, B., Lee, S. W., Silva Morales, M., Hogquist, K. A., Jameson, S. C., Mueller, D., Rothstein, J., Blazar, B. R., Cheng, C., Noelle, R. J., Zhao, Y., Mercier, I. L., Morales, M. S. and Noelle, R. J.(2020). VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance. Science 367(6475). DOI: 10.1126/science.aay0524

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