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Data analysis

AH Alyson Haslam

Last updated date: Feb 12, 2021 Views: 1032 Forks: 0

original An abbreviated version of this protocol was published in eLife in Jun, 2019
A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals
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Data analysis protocol for “Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals”

Using Microsoft Excel and R (package tidyverse), summary statistics were calculated for reversal articles as frequencies and percentages for the following:

  • Overall and for each journal
  • by economic status (as defined by the World Bank, and stratified by high-income vs low- and middle-income)
  • by intervention type (medication, procedure, vitamins/supplements/food, device, system intervention, optimization of a procedure, behavioral therapy, screening test, treatment algorithm, diagnostic instrument, radiation, and over-the-counter medication)
  • by medical discipline (cardiovascular disease, public heal/preventive medicine, critical care medicine, obstetrics/gynecology, neurology/neurosurgery, oncology, orthopedic, pulmonary disease, pediatrics, gastroenterology/hepatology, endocrinology, diabetes, metabolism, psychiatry, nephrology, infectious disease, surgery, urology, allergy/immunology, anesthesiology, rheumatology, ophthalmology)
  • funding category (industry sources, non-industry sources, a combination of industry and non-industry, a combination of non-industry plus insurance or development bank, and funding sources not available) 

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word Data analysis protocol_elife.docx download
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How to cite：
Readers should cite both the Bio-protocol preprint and the original research article where this protocol was used:
  1. Haslam, A(2021). Data analysis. Bio-protocol Preprint. bio-protocol.org/prep836.
  2. Herrera-Perez, D., Haslam, A., Crain, T., Gill, J., Livingston, C., Kaestner, V., Hayes, M., Morgan, D., Cifu, A. S. and Prasad, V.(2019). A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals. eLife. DOI: 10.7554/eLife.45183

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