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Preprint

Fc.IL-2 muteins

DC Daniel J. Campbell
MG Marc A. Gavin

Last updated date: Feb 1, 2021 Views: 932 Forks: 0

original An abbreviated version of this protocol was published in Science Immunology in Aug, 2020
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
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Fc.Mut24

MDMRVPAQLLGLLLLWLRGARC

RGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDV

SEDDPDVQISWFVNNVEVHTAQTQTHREDYGSTLRVVSALPIQHQDWMSG

KEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLT

CMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKN

WVERNSYSCSVVHEGLHNHHTTKSFSRTPG

GGGGS

APTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKL

PRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENF

ISRIRDTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFAQSIISTSPQ

 

Red = mutations

Signal sequence-Fc-Linker-IL2.Mut24

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How to cite：
Readers should cite both the Bio-protocol preprint and the original research article where this protocol was used:
  1. Campbell, D and Gavin, M(2021). Fc.IL-2 muteins. Bio-protocol Preprint. bio-protocol.org/prep801.
  2. Khoryati, L., Pham, M. N., Sherve, M., Kumari, S., Cook, K., Pearson, J., Bogdani, M., Campbell, D. J. and Gavin, M. A.(2020). An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice . Science Immunology 5(50). DOI: 10.1126/sciimmunol.aba5264

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