Loading of TH588 and Ce6 to SCLMs

1. 3 mg of the TH588 (purchased from MedChemExpress) was dissolved in DMSO (400 µL) to form a 25 mM solution.

2. 6 mg of the Ce6 (purchased from J&K Chemicals) was dissolved in DMSO (500 µL) to form a 20 mM solution.

3. 1-40 µL of TH588 and/or 0.5-10 µL of Ce6 was added to 5 mL solution containing 10 mg·mL⁻¹ SCLMs.

4. The solution was sonicated vigorously for 20 s to allow the loading of TH588 and/or Ce6 into the PPO core of SCLMs.

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