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Statistical analysis

TP Thanaphong Phongpreecha
TM Thomas J. Montine

Last updated date: Apr 8, 2021 Views: 856 Forks: 0

original An abbreviated version of this protocol was published in Science Advances in Nov, 2020
Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases
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Boot strapped model reduction steps
 

After obtaining the full model (all features included):

1. Sampling with replacement (using sampling size the same as the number of total samples).

2. Predict the probability using, for example, 1 feature and its associated averaged weight (in this case this feature would be the one with highest absolute average weight).

3. Evaluate P values against the ground truth of the sampled observations.

4. Repeat these steps 100 times and get the median p value performance (each time the sampled observations in step 1 would be different).

5. Repeat these steps for 2, 3, 4, 5 features and so on.

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How to cite：
Readers should cite both the Bio-protocol preprint and the original research article where this protocol was used:
  1. Phongpreecha, T and Montine, T(2021). Statistical analysis. Bio-protocol Preprint. bio-protocol.org/prep1005.
  2. Phongpreecha, T., Fernandez, R., Mrdjen, D., Culos, A., Gajera, C. R., Wawro, A. M., Stanley, N., Gaudilliere, B., Poston, K. L., Aghaeepour, N. and Montine, T. J.(2020). Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases. Science Advances 6(48). DOI: 10.1126/sciadv.abd5575

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