Hello, I was confused because of TO1. In the paper from the...

protocol Protocol: Purification of RNA Mango Tagged Native RNA-protein Complexes from Cellular Extracts Using TO1-Desthiobiotin Fluorophore Ligand
Hello,

I was confused because of TO1.
In the paper from the same authors (2014, RNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking)
it is mentioned, that TO1 binds nonspecifically to DNA and RNA that lead to high background,
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