Do I need to keep giving the drug after successful modeling? How long can a DOCA pellet be administered continuously?

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Duan rui xue
Jan 19, 2024
protocol Protocol: Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model

I would like to study the improvement of blood pressure in rats with aldosteronism by constructing the DOCA-Salt rat model with a certain drug.Do I need to keep giving the drug after successful modeling? How long can a DOCA pellet be administered continuously?

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John P Collister Author Answered Jan 24, 2024

University of Minnesota Saint Paul

I"m sorry we have only modeled the DOCA hypertension for 21 days. I am unsure how much longer the DOCA will be absorbed

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