what is the advantage of this technology in various applications?

Our avidity-based sensors provide an alternative to conventional antibodies. These proteins can be genetically encoded, expressed in mammalian cells and used to assess the kinetics of formation and disappearance of specific histone ubiquitination signals in live cells in real-time (e.g., assess H2AK13/15Ub throughout the cell cycle). Moreover, these sensors can also detect histone ubiquitination in fixed samples. This approach is particularly attractive for histone PTMs for which there are no antibodies available.