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KT Kristin Torgersen
SB Shahram Bahrami
OF Oleksandr Frei
AS Alexey Shadrin
KC Kevin S. O’ Connell
OS Olav B. Smeland
JM John Munkhaugen
SD Srdjan Djurovic
TD Toril Dammen
OA Ole A. Andreassen
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In the present study, GWAS summary statistics data on neuroticism were available for 432,109 individuals (372,903 individuals from the UK Biobank28 and 59,206 individuals from 23andMe, Inc29.) who completed a questionnaire on neuroticism and provided DNA for genome-wide genotyping14. We meta-analysed the two GWAS summary statistics using METAL30.

Between 2006 and 2010, 502,655 community-dwelling people aged between 37 and 73 years and living in the United Kingdom were recruited to the UK Biobank study and completed the baseline survey (http://www.ukbiobank.ac.uk)28. They underwent assessments of cognitive and physical functions, mood and personality. They provided blood, urine, and saliva samples for future analysis, completed questionnaires about their social backgrounds and lifestyle and agreed that their information could be used in research.

The 23andMe sample was based on self-reported information from more than 1,000,000 individuals (90% participating in research), through a direct-to-consumer online genetic-testing service since 200629. Participants provided informed consent and participated in the research online, under a protocol approved by the external AAHRPP-accredited IRB, Ethical & Independent Review Services (E&I Review).

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