Each structural MRI had a segmented ICC mask created by an automated multi-atlas segmentation procedure (Aljabar et al., 2009) followed by human quality control. Briefly, the multi-atlas segmentation consisted of nonlinear warps of 15 template brain images, in which the ICC has been carefully delineated by human operators, onto a target whole-head MRI. The deformed template ICC masks were overlaid in the target native space and a voting scheme is conducted to ascertain a consensus of ICC locations within the target image. Final cleanup to remove inevitable mistakes was performed by human operators using a slice-based visualization tool.
Do you have any questions about this protocol?
Post your question to gather feedback from the community. We will also invite the authors of this article to respond.