Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

2.4.1. Resting‐state functional connectivity

AC Antonio M. Chiarelli
CS Carlo Sestieri
RN Riccardo Navarra
RW Richard G. Wise
MC Massimo Caulo
request Request a Protocol
ask Ask a question
Favorite

Resting‐state functional connectivity (RsFC) matrices were built by evaluating pairwise associations of BOLD signals in the 90 ROIs while accounting for the contribution of the global signal. Each normalized (z‐scored) ROI's BOLD timecourse was regressed on each other normalized ROI's BOLD timecourse using the normalized average (among the 90 ROIs) BOLD signal as an additional independent variable within a general linear model (GLM) framework (Murphy & Fox, 2017). Note that this GLM analysis is not commutative between ROIs, generating a nonsymmetric connectivity matrix. However, to evaluate undirected connections, the average between the lower and the upper diagonal portions of the connectivity matrices was computed. The latter computational step delivered 4,005 meaningful rsFC connections. An additional control analysis focused exclusively on positive correlations by zeroing out negative correlation values.

Copyright and License information:  ©2021 The Authors. published by Wiley Periodicals LLC.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

0/150

tip Tips for asking effective questions

+ Description

Write a detailed description. Include all information that will help others answer your question including experimental processes, conditions, and relevant images.

post Post a Question
0 Q&A