Data were analyzed using SPSS (IBM SPSS 23.0, SPSS Inc.) and GraphPad Prism (GraphPad Prism 8.0, USA), with all data expressed as medians (25th percentile and 75th percentile) (for data with skewed distribution). Receiver operating characteristic (ROC) curves were also used to calculate the ADR cut-off, and the Mann–Whitney U and chi-square tests were also used as appropriate. Univariate and multivariate analyses were performed, and survival analysis was performed using Kaplan-Meier and log-rank tests. Statistical significance was set at P < 0.05 for all analyses.
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