All results are expressed as median and interquartile range if not stated otherwise. In the present study a descriptive statistical analysis has been performed. No formal inference was performed due to the small sample size. Statistical significance was assessed using a two-tailed Mann–Whitney test to compare continuous outcomes between groups. T test was used for splicing entropy result analysis. Levels of significance were defined as p ≤0.05 (*), p <0.01 (**), p <0.001 (***), and p <0.0001 (****). Statistical testing was performed using Prism GraphPad (Version 5.0f, La Jolla, CA). Graphs were created using the same software.
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