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In accordance with the principle of “PICOS,” it was defined as following: (1) P: the children with SDNS or FRNS; (2) I: treated with MMF or other immunosuppressants (TAC, CsA, and levamisole; (3) C: MMF vs. other immunosuppressants (TAC, CsA, and levamisole); (4) O: relapse-free survival rate within 1 year, the number of relapses within 1 year, cumulative prednisone dosage, and incidence of adverse reactions; (5) S: a meta-analysis of RCTs and a prospective cohort study.

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