TCGA RNA sequencing level 3 normalized data were downloaded from TCGA Data Portal and imported into R (Version 4.0.3) using TCGAbiolinks (Version 2.16.4) functions GDCquery, GDCdownload and GDCprepare for further analysis. 27 Among cases having immunostaining data of ER, PR and HER2, 122 TNBC cases have been selected, among them, there were 14 cases of MBC. Samples that are molecularly classified as LAR was identified in a previous article using Lehmann classifier and were used in this study. 28 In total, there are 38 cases of the LAR subtype of TNBC.
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