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Synthesis preparation

KC Klaudia A. Cybulska
VB Vera Bloemers
LP Lars R. Perk
PL Peter Laverman
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Preparation of Trasis AIO synthesiser Prior to the production, the synthesiser underwent internal tests. After completion, the cassette was installed and evaluated using an automatic sequence to ensure that all connections had been secured in place and all components functioned properly.

Preparation of dispensing Dispensing was performed in a GMP Grade A hot cell equipped with fully automated open vial dose divider system from Von Gahlen. The incoming product line from the Trasis AIO was first rinsed with ethanol, followed by water for injection. A new dispensing set and appropriate sterile filters were then installed.

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