4.1.3. Induction of VCR-Induced Peripheral Neuropathy

Peripheral painful neuropathy was induced in mice by the administration of vincristine sulfate, according to the previously reported method [2,28]. Briefly, vincristine sulfate (75 μg kg, i.p.) was administered intraperitoneally once-daily for 10 consecutive days (from day 1–10). A treatment schedule is depicted in Figure 16.

A schematic representation of the in vivo study design.