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3.7. Metabolic Pathways Enrichment Analysis

PT Piaopiao Tan
CZ Chaozhen Zeng
CW Chang Wan
ZL Zhe Liu
XD Xujie Dong
JP Jiqing Peng
HL Haiyan Lin
ML Mei Li
ZL Zhixiang Liu
MY Mingli Yan
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To reveal the mechanism of metabolic pathway variation in different samples, the differential metabolites were carried out metabolic pathway enrichment analysis based on the KEGG database (http://www.kegg.jp/kegg/pathway.html, accessed on 12 June 2021) [97]. Their KEGG ID and pathway were found, then the number of metabolites enriched in corresponding pathway was calculated. The pathway with p-value ≤ 0.05 was selected as enriched pathway, its calculation formula is

N: The total number of metabolites, n: The number of differential metabolites, M: the number of metabolites annotated as a specific pathway, m: the number of differential metabolites annotated as a specific pathway.

Copyright and License information:  ©2021 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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