Functional annotation and interpretation were performed in DAVID database (Database for visualization, annotation and integrated discovery, http://david.abcc.ncifcrf.gov/) to discover biological meaning of genes [22]. Gene Ontology (GO) is a powerful method to analyze biological process, cellular component and molecular function among different genes. Kyoto Encyclopedia of Genes and Genomes (KEGG), a basis for gene function and genomic information links, is used to analyze information about signaling pathway relationships. GO and KEGG were performed for identified DEGs in DAVID database, P < 0.05 was set as threshold for statistically significant definition.
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