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Cancer cell line encyclopedia (CCLE) database analysis

HZ He Zhou
YX Yong Xiong
ZL Zuoliang Liu
SH Songlin Hou
TZ Tong Zhou
YX Yongfu Xiong
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CCLE (https://portals.broadinstitute.org/ccle/home) is an open-access database covering large-scale deep sequencing information of 947 human cancer cell lines from > 30 varieties of tissue sources. The mRNA expression of the CBX family in cell lines derived from different tumor types was analyzed by CCLE, to deepen the understanding of DNA mutations, gene expression and chromosome copy number information for specific genes. Gene expression data of the CBX family was downloaded directly from the CCLE website. According to the website, raw microarray data of CRC cell lines were converted to a single value for each probeset using the Robust Multi-array Average algorithm and quantile normalization.

Copyright and License information: The Author(s) ©2021
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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