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Diffusion tensor imaging analysis

GC Gianluca Coppola
AR Antonio Di Renzo
ET Emanuele Tinelli
BP Barbara Petolicchio
VP Vincenzo Parisi
MS Mariano Serrao
CP Camillo Porcaro
MF Marco Fiorelli
FC Francesca Caramia
JS Jean Schoenen
VP Vittorio Di Piero
FP Francesco Pierelli
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Image data processing was performed with the FSL 6.0 software package (FMRIB Image Analysis Group, Oxford, England; https://fsl.fmrib.ox.ac.uk/fsl/fslwiki).

Diffusion data were corrected for susceptibility and eddy current distortions, FDT (FMRIB’s Diffusion Toolbox) was employed for local fitting of diffusion tensors. DTI metrics maps were created: FA (fractional anisotropy), MD (mean diffusivity), AD (axial diffusivity), and RD (radial diffusivity).

Two regions of interest (ROI) were defined for each subject, covering the thalamus on the right and left sides of each slice. The medial boundaries on each slice were determined using the CSF as limit, while lateral boundaries were ascertained using FA maps to exclude the internal capsule.

We calculated mean FA, MD, AD, and RD values in each region for every participant by averaging voxels included in the ROI.

Copyright and License information: The Author(s) ©2021
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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