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2.2.3. CamSol

MF Manuel Flores-León
DL Diana F. Lázaro
LS Liana Shvachiy
AK Anita Krisko
TO Tiago F. Outeiro
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CamSol is a free online software that predicts the solubility of proteins. [27] The use of this method requires either the knowledge of the native structure of the target protein to calculate the structure-corrected solubility profile or the intrinsic solubility profile can be predicted based on the amino acid sequence.

The profiles consist of a score for each residue and it characterizes their impact on the overall solubility of the protein. This sequence-based method predicts protein solubility and generic aggregation propensity. The lower the score is, the lower the solubility of the protein, i.e. the higher the aggregation propensity. Proteins with the intrinsic solubility lower than −1.5 (a.u.) were deemed aggregation prone.

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