Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Randomisation and masking

TH Timothy S C Hinks
LC Lucy Cureton
RK Ruth Knight
AW Ariel Wang
JC Jennifer L Cane
VB Vicki S Barber
JB Joanna Black
SD Susan J Dutton
JM James Melhorn
MJ Maisha Jabeen
PM Phil Moss
RG Rajendar Garlapati
TB Tanya Baron
GJ Graham Johnson
FC Fleur Cantle
DC David Clarke
SE Samer Elkhodair
JU Jonathan Underwood
DL Daniel Lasserson
IP Ian D Pavord
SM Sophie Morgan
DR Duncan Richards
request Request a Protocol
ask Ask a question
Favorite

Patients were randomly assigned (1:1) to either azithromycin plus standard care or standard care alone using a web-based automated service, with a minimisation algorithm to ensure balanced allocation across treatment groups, stratified by centre, sex, and presence of hypertension and diabetes. To ensure the unpredictability of treatment allocation, the first 30 participants were randomly assigned by simple randomisation and the minimisation algorithm included a probabilistic element (participants had an 80% chance of being allocated to the treatment, which minimised imbalance between the groups). Patients, investigators, and health-care providers were not masked to study drug assignment.

Copyright and License information:  ©2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

0/150

tip Tips for asking effective questions

+ Description

Write a detailed description. Include all information that will help others answer your question including experimental processes, conditions, and relevant images.

post Post a Question
0 Q&A