Statistical analysis

The Kaplan–Meier “survival” package was applied to the Cox regression model. The log‐rank test and Kaplan Meier method were used to formulate survival curves. A chi‐square (X2) test was used to compare categorical variables. Differential analysis and normalization were adopted on the basis of the “Limma” package. As a nonparametric statistical hypothesis test, the Wilcoxon rank‐sum test was applied to the comparative analysis between the two groups. The R project (Version 4.0.3) laid the basis for all statistical analyses, where significance was identified by p < 0.05.