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2.4. Construction of protein-protein interaction network
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Search Tool for the Retrieval of Interacting Genes/Proteins(STRING) was used for the functional interactions among DEGs at the combined score of more than 0.5 [23]. Molecular Complex Detection (MCODE) plugin from Cytoscape was utilized for distinguishing the module that best represents the clusters of DEGs [24]. The modules which met the cutoff criteria of node > 10 and the score >10 were selected. Further, the resulted modules were subjected to DAVID for pathway analysis.
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