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Validation of the Hub Genes in Datasets and Analysis of the Receiver Operating Characteristic (ROC) Curve
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The expression data of hub genes extracted from the merged dataset and verification dataset GSE36961 were utilized to validate the differential expression of hub genes in HCM. The “glmnet” package was used to construct a logistic regression model for hub genes.23 Additionally, the merged dataset was used as a training set to construct the model while GSE36961 was used for external validation. Subsequently, we used the “pROC” package to perform ROC curve analysis.24
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