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The Anti-CD19-CAR T Cell Therapy

HZ Haibo Zhu
HD Haobin Deng
JM Juan Mu
CL Cuicui Lyu
YJ Yanyu Jiang
QD Qi Deng
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All the thirteenR/R DLBCL and B-ALL patients had received the clinical trial of anti-CD19 CAR-T cell expressing anti-CD19 scFv and 4–1BB-CD3ζ costimulatory-activation domains therapy (ChiCTR-ONN-16009862) in our hospital. The leukapheresis was done when they were enrolled in this anti-CD19-CAR T cell therapy clinical trial. Then the procedures for cell production and quality-control assays were conducted according to our literature before.14 All the patients received lymphodepleting chemotherapy with fludarabine (30 mg/m2) and cyclophosphamide (400 mg/m2) from day −4 to day −2. Autologous anti-CD19-CAR T cells were infused on day 0 in R/R DLBCL and B-ALL patients (2x106 cells/kg).

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