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Protein-protein interaction (PPI) networks were generated by retrieving relatively high confidence protein interactions (confidence score cut-off of 0.7) from the STRING database (Szklarczyk et al., 2015). The resulting network was visualized using Cytoscape and network metrics (degree and betweenness centrality) were calculated using Network Analyzer v.2.7 in Cytoscape plugin (Kohl et al., 2011) (Supplementary Table 1, 2).
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