The regulated GO48 terms were derived using the clusterProfiler R package49 and visualized by mapping the percentage of regulated genes to the total GO term gene count against significant gene counts and adjusted P values per term. We visualized the GO term as a heat map, where each row represents a differentially expressed gene belonging to the term and each column represents a sample. To ensure visual differentiation between the rows not being skewed by highly expressed genes, the values of each sample were converted to z-scores with respect to the individual genes.
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