Palatability Questionnaire

The questionnaire was structured as follows: 5 questions were posed asking the subjects to respond: “1. Rate the oral sensation/mouthfeel of the drug product”; “2. Rate the taste of the drug product”; “3. How strong is the taste?”; “4. Rate the aftertaste of the drug product”; and “5. How strong is the aftertaste?”. For questions 1, 2, and 4, the range of responses was: “very unpleasant, unpleasant, no sensation/mouthfeel, pleasant, very pleasant.” For questions 3 and 5, the range of responses was: “very strong, strong, moderate, mild, no taste.” Subjects were given time to read the palatability questionnaire and consider its content prior to responding. They were permitted ask questions about the meaning (eg, “what is meant by … ”) of the questions at any time during questionnaire administration. Subjects were required to complete the questionnaire within 10 minutes of consuming the tablet and were instructed to initial the document once completed.

Clinic staff were instructed to ensure that only one response was given per question.