Elastase-induced lung emphysema model

JP Jin-Soo Park
RC RyeonJin Cho
EK Eun-Young Kang
YO Yeon-Mok Oh
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For the experimental emphysema model, we generated elastase-induced model mice using previously described methods16. The mice were intratracheally injected with porcine pancreatic elastase (PPE, Sigma-Aldrich, St. Louis, MO, USA) on day 0. The mice were treated with Slit2 by intranasal administration on days 7–13 and were sacrificed on day 14, after which the lungs were harvested.

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