A study population of 112 unrelated patients of Caucasian descent fulfilling McDonald 2010 criteria for MS was included between May and November 2017 at the University Hospitals Leuven. We specifically selected untreated patients and patients treated with IFN-β or fingolimod. Overlap with our earlier work (1) is 14% (6/41 untreated), 21% (9/42 IFN-β) and 34% (10/29 fingolimod), respectively, where overlapping patients were sampled at an earlier time-point. The same treating physician (B.D.) collected clinical and demographic data during patient follow-up ( Table 1 ). The study was approved by the Ethics committee of the University Hospitals Leuven (S60222).
Study population.
(SD, Standard deviation; BO, bout onset; PP, primary progressive; MSSS, multiple sclerosis severity score).
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